| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Son of sevenless homolog 2; SOS-2; SOS2; |
| Entrez GeneID | 6655; |
| WB Predicted band size | 153kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SOS2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SOS2抗体的3篇文献示例(内容基于学术知识总结，非真实文献)：
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1. **文献名称**：*SOS2-Mediated RAS Activation in Breast Cancer Models*
**作者**：A. Weiss et al. (2009)
**摘要**：研究通过特异性SOS2抗体验证了SOS2在乳腺癌细胞中激活RAS信号通路的作用，揭示其与肿瘤增殖的相关性，并证明抗体阻断可抑制体外肿瘤生长。
2. **文献名称**：*Structural and Functional Analysis of SOS1/2 Proteins in Development*
**作者**：E. Santos et al. (2003)
**摘要**：比较SOS1与SOS2蛋白的结构差异，利用SOS2抗体进行组织特异性表达分析，发现SOS2在小鼠胚胎发育中的独特调控功能。
3. **文献名称**：*Targeting SOS2 in Metabolic Syndrome Pathways*
**作者**：R. Roskoski et al. (2018)
**摘要**：开发高亲和力SOS2单克隆抗体，证实其在肝脏代谢模型中对胰岛素信号通路的调节作用，提示SOS2可能成为代谢疾病的潜在治疗靶点。
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**备注**：以上文献为虚构示例，实际研究中建议通过PubMed、Google Scholar等平台检索关键词(如"SOS2 antibody"、"SOS2 RAS signaling")获取真实文献。
**Background of SOS2 Antibody**
The SOS2 antibody is a research tool targeting SOS2 (Son of Sevenless homolog 2), a guanine nucleotide exchange factor (GEF) within the SOS protein family. SOS proteins, including SOS1 and SOS2. regulate cell signaling by activating RAS GTPases, which mediate critical pathways like RAS-MAPK involved in cell proliferation, differentiation, and survival. Structurally, SOS2 contains a catalytic Dbl homology (DH) domain and a pleckstrin homology (PH) domain, facilitating interactions with membrane-bound receptors and downstream effectors.
While SOS1 is ubiquitously expressed and extensively studied in cancer, SOS2 exhibits more restricted _expression (e.g., heart, skeletal muscle, placenta) and plays distinct roles in cellular responses, including stress signaling and developmental processes. Dysregulation of SOS2 has been linked to cardiovascular disorders and certain cancers, though its mechanisms remain less characterized than SOS1.
SOS2 antibodies are essential for detecting SOS2 expression, localization, and post-translational modifications in techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are typically validated for specificity against SOS2 isoforms or phosphorylated forms to avoid cross-reactivity with SOS1. Researchers prioritize antibodies based on host species (e.g., rabbit, mouse), clonality (monoclonal/polyoclonal), and application-specific validation data.
Overall, SOS2 antibodies are pivotal for elucidating SOS2's role in RAS signaling and disease pathogenesis, offering potential insights for therapeutic targeting.
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