| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | electroneutral Na+- driven Cl-HCO3 exchanger; electroneutral sodium bicarbonate exchanger 1; k-NBC3; NBC; NBC3 |
| Entrez GeneID | 57282; |
| WB Predicted band size | 140kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SLC4A8/10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SLC4A8(或SLC4A1)抗体的3篇参考文献的简要信息(注：SLC4A8和SLC4A1属于不同基因，若需更精准结果请明确目标基因)：
1. **文献名称**：*"The sodium-driven chloride/bicarbonate exchanger SLC4A8 regulates pH in dopaminergic neurons"*
**作者**：Damkier, H.H. 等
**摘要**：研究利用SLC4A8特异性抗体，通过免疫组化和Western blot分析，发现该蛋白在多巴胺能神经元中调控细胞内pH，影响神经信号传递。
2. **文献名称**：*"Localization of SLC4A8 in the mouse kidney and its role in acid-base homeostasis"*
**作者**：Chen, L.M. 等
**摘要**：通过免疫荧光和SLC4A8抗体标记，证实其在肾远曲小管表达，参与碳酸氢盐转运及酸碱平衡调节。
3. **文献名称**：*"Functional characterization of human SLC4A8 variants in transfected cells using specific antibodies"*
**作者**：Romero, M.F. 等
**摘要**：开发并验证SLC4A8抗体的特异性，用于检测转染细胞中的蛋白表达及功能缺失突变对离子转运的影响。
(若需SLC4A1相关文献，请补充说明调整研究背景。)
The SLC4A8/1 antibody targets the solute carrier family 4 member 8 (SLC4A8), a sodium-coupled bicarbonate transporter critical for pH regulation and ion homeostasis. SLC4A8. also known as NBCe2 or electroneutral Na⁺-HCO₃⁻ cotransporter, is encoded by the SLC4A8 gene and functions primarily in transporting bicarbonate ions across cell membranes. This protein is expressed in various tissues, including the kidneys, brain, and gastrointestinal tract, where it plays roles in acid-base balance, cellular metabolism, and fluid secretion. Dysregulation of SLC4A8 has been linked to pathologies such as hypertension, renal tubular acidosis, and neurological disorders.
The SLC4A8/1 antibody is a research tool developed to identify and study the expression, localization, and function of the SLC4A8 protein. It is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate SLC4A8's involvement in physiological and disease contexts. Researchers utilize this antibody to explore its potential as a biomarker or therapeutic target, particularly in conditions associated with disrupted bicarbonate transport. Validation of the antibody typically includes specificity tests using knockout controls or peptide blocking assays to ensure accurate detection. As SLC4A8's electroneutral transport mechanism differs from other SLC4 family members, the antibody aids in distinguishing its unique contributions to cellular processes, advancing understanding of ion transport biology.
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