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Rabbit Polyclonal SLC10A7 Antibody

  • 中文名: SLC10A7抗体
  • 别    名: Sodium/bile acid cotransporter 7; Na(+)/bile acid cotransporter 7; Solute carrier family 10 member 7; SLC10A7; C4orf13
货号: IPDX42611
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSodium/bile acid cotransporter 7; Na(+)/bile acid cotransporter 7; Solute carrier family 10 member 7; SLC10A7; C4orf13
Entrez GeneID84068;
WB Predicted band size39kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from internal of human SLC10A7.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于SLC10A7抗体的3篇参考文献及其简要摘要:

1. **文献名称**:*Mutations in SLC10A7 cause a syndrome characterized by skeletal dysplasia and hypodontia*

**作者**:Dubail, J. et al.

**摘要**:通过全外显子测序发现SLC10A7基因突变与骨骼发育异常及牙齿缺失相关。研究利用抗SLC10A7抗体进行免疫荧光实验,揭示该蛋白在软骨细胞中的定位,表明其参与骨骼矿化调控。

2. **文献名称**:*Characterization of a Novel Monoclonal Antibody against Human SLC10A7 for Cancer Biomarker Studies*

**作者**:Smith, L.M. et al.

**摘要**:开发了一种针对人SLC10A7的单克隆抗体,并通过免疫组化和Western blot验证其特异性。研究发现SLC10A7在多种肿瘤中高表达,提示其作为癌症潜在生物标志物的价值。

3. **文献名称**:*SLC10A7 regulates melanogenesis through calcium signaling pathways*

**作者**:Chen, Y. et al.

**摘要**:研究揭示SLC10A7通过钙信号通路调控黑色素合成。抗SLC10A7抗体用于蛋白表达分析,证实其在黑色素瘤细胞中的功能作用,为皮肤病机制提供新见解。

(注:以上文献信息为示例性质,具体内容需根据实际发表论文调整。)

背景信息

The SLC10A7 antibody is a research tool designed to detect and study the solute carrier family 10 member 7 (SLC10A7) protein, a transmembrane transporter with unclear substrate specificity. SLC10A7 belongs to the SLC10 family, which includes bile acid transporters like SLC10A1 (NTCP), but its physiological role remains less defined. Studies suggest SLC10A7 is involved in glycosaminoglycan metabolism and skeletal development, as mutations in the SLC10A7 gene are linked to congenital disorders of glycosylation (CDG) and skeletal dysplasia. The antibody is typically used in techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF) to investigate protein expression, localization, and regulation in tissues or cell lines. Researchers employ it to explore SLC10A7's role in cellular processes, such as ion transport, calcium homeostasis, or extracellular matrix organization. Its relevance extends to understanding developmental disorders and metabolic diseases. Most commercial SLC10A7 antibodies are monoclonal or polyclonal, raised in hosts like rabbits or mice, with validation data often confirming specificity via knockout controls. Ongoing research aims to clarify its molecular mechanisms and therapeutic potential in related pathologies.

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