| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sodium channel protein type 7 subunit alpha; Sodium channel protein type VII subunit alpha; Putative voltage-gated sodium channel subunit alpha Nax; Sodium channel protein cardiac and skeletal muscle subunit alpha; SCN7A |
| Entrez GeneID | 6332; |
| WB Predicted band size | 200kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SCN7A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SCN7A抗体的3篇假设性参考文献示例(注：实际文献可能需要通过学术数据库验证)：
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1. **文献名称**：*"Characterization of a polyclonal antibody against SCN7A for sodium channel detection in murine tissues"*
**作者**：Garcia R, et al.
**摘要**：本研究开发了一种兔源多克隆抗体，用于检测小鼠心脏和周围神经中的SCN7A蛋白。通过免疫印迹和免疫组化验证其特异性，发现SCN7A在心肌细胞膜和背根神经节神经元中有显著表达，提示其潜在电生理功能。
2. **文献名称**：*"SCN7A expression in human colorectal cancer: an immunohistochemical study using a novel monoclonal antibody"*
**作者**：Tanaka M, et al.
**摘要**：研究利用新开发的小鼠单克隆抗体，通过免疫组织化学分析SCN7A在结直肠癌组织中的表达。结果显示，SCN7A在癌变组织中表达上调，且与患者预后不良相关，提示其可能作为肿瘤标志物。
3. **文献名称**：*"Functional validation of SCN7A antibodies in modulating neuronal excitability in vitro"*
**作者**：Wang L, et al.
**摘要**：通过体外电生理实验，验证两种商业SCN7A抗体对神经元钠电流的阻断效果。研究发现，抗体可部分抑制背根神经节细胞的钠离子流，支持SCN7A在动作电位调控中的作用。
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**注意**：上述文献为示例，实际研究中SCN7A相关抗体文献较少，建议结合具体需求通过PubMed或Google Scholar检索最新文献(关键词：SCN7A antibody, Nav1.7. sodium channel antibody)。SCN7A可能与其他钠通道基因(如SCN9A)存在命名混淆，需注意区分。
The SCN7A antibody is a research tool designed to detect and study the SCN7A protein, encoded by the SCN7A gene (sodium voltage-gated channel alpha subunit 7). SCN7A, also known as Nav2.1. belongs to the voltage-gated sodium channel (VGSC) family, which plays critical roles in generating and propagating action potentials in excitable cells. While most VGSC members (e.g., Nav1.1–Nav1.9) are well-characterized in neuronal or muscular function, SCN7A is distinct in its expression profile and physiological role. It is primarily expressed in non-excitable tissues, such as the heart, liver, and uterus, and has been implicated in regulating cellular processes like proliferation, migration, and electrolyte balance.
SCN7A antibodies are essential for investigating the protein's expression patterns, subcellular localization, and interactions in both normal and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of SCN7A has been explored in conditions such as hypertension, cardiac arrhythmias, and cancer, though its precise mechanistic contributions remain under study.
These antibodies enable researchers to dissect SCN7A's unique biophysical properties and its potential as a therapeutic target. However, challenges persist in ensuring antibody specificity due to structural similarities among sodium channel isoforms. Validated SCN7A antibodies are crucial for advancing understanding of its role in health and disease, bridging gaps in sodium channel biology beyond classical neuronal and muscular functions.
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