| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein phosphatase subunit G5PR; Rhabdomyosarcoma antigen MU-RMS-40.6A; Rhabdomyosarcoma antigen Mu-RMS-40.6C; |
| Entrez GeneID | 55012; |
| WB Predicted band size | 53kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human PPP2R3C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PPP2R3C抗体的参考文献示例，按您的要求整理：
1. **文献名称**：*PPP2R3C Expression in Breast Cancer: A Novel Prognostic Biomarker*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化(使用PPP2R3C特异性抗体)分析了乳腺癌组织中PPP2R3C蛋白的表达水平，发现其低表达与患者预后不良相关，提示其在肿瘤抑制中的潜在作用。
2. **文献名称**：*Role of PPP2R3C in Neuronal Differentiation Revealed by Antibody-Based Knockdown Assays*
**作者**：Lee J, et al.
**摘要**：利用PPP2R3C抗体进行Western blot和免疫荧光实验，发现PPP2R3C通过调控MAPK通路影响神经干细胞分化，为神经发育障碍提供了新机制见解。
3. **文献名称**：*PPP2R3C Genetic Variants and Protein Dysregulation in Autoimmune Diseases*
**作者**：Garcia R, et al.
**摘要**：通过ELISA和免疫沉淀(使用抗PPP2R3C抗体)，研究揭示了PPP2R3C单核苷酸多态性(SNPs)与系统性红斑狼疮患者中磷酸酶活性异常的关联。
4. **文献名称**：*Functional Characterization of PPP2R3C in Cell Cycle Regulation Using CRISPR/Cas9 and Antibody Validation*
**作者**：Chen X, et al.
**摘要**：结合CRISPR/Cas9敲除技术和PPP2R3C抗体验证，证明PPP2R3C通过调控CDK1磷酸化参与细胞周期检查点，影响肝癌细胞增殖。
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**备注**：上述文献为示例，实际引用时请核实真实数据库(如PubMed、Web of Science)中的最新研究。若需具体文献，建议以“PPP2R3C antibody”、“PPP2R3C protein expression”为关键词检索。
The PPP2R3C antibody targets the protein encoded by the PPP2R3C gene, also known as Protein Phosphatase 2 Regulatory Subunit B''Gamma. This protein is a key regulatory component of Protein Phosphatase 2A (PP2A), a serine/threonine phosphatase critical for cellular processes like cell cycle regulation, signal transduction, and apoptosis. As part of the B''/PR72 subfamily, PPP2R3C modulates PP2A’s substrate specificity, enzymatic activity, and subcellular localization by forming dynamic holoenzyme complexes with catalytic and scaffold subunits. It plays roles in DNA damage response, metabolic regulation, and neuronal development, with tissue-specific expression patterns observed in brain, testis, and muscle.
Antibodies against PPP2R3C are essential tools for studying its expression, interactions, and function in both normal and pathological contexts. They are used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Dysregulation of PPP2R3C has been implicated in cancers, neurodegenerative disorders, and metabolic diseases, making it a potential biomarker or therapeutic target. Specificity of these antibodies is typically validated via knockout/knockdown controls or epitope mapping. Recent studies also explore PPP2R3C’s structural motifs, such as conserved repeats, which may influence its regulatory roles. Genetic variants in PPP2R3C are occasionally linked to developmental disorders, underscoring its physiological importance.
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