Rabbit Polyclonal P2R3B Antibody

The P2X3 receptor (P2RX3), a member of the purinergic receptor family, is an ATP-gated ion channel predominantly expressed in sensory neurons. It plays a critical role in mediating nociceptive signaling and visceral mechanosensation. Dysregulation of P2X3 activity is linked to chronic pain conditions, refractory cough, and bladder hypersensitivity. P2R3B antibody, likely targeting the P2X3 receptor or its splice variants, has emerged as a research tool and therapeutic candidate. Studies suggest that inhibiting P2X3 via antibodies or antagonists (e.g., gefapixant) may alleviate pathologies like overactive bladder or chronic cough by attenuating ATP-mediated hyperexcitability of sensory nerves. However, the exact epitope and specificity of "P2R3B" require clarification, as nomenclature inconsistencies exist. Current research focuses on optimizing antibody selectivity to minimize off-target effects, particularly in the central nervous system, given P2X3's peripheral predominance. Preclinical models highlight its potential, but clinical translation remains ongoing, with challenges including bioavailability and long-term safety. This antibody class represents a promising avenue for treating ATP-driven sensory disorders, bridging molecular insights with unmet clinical needs.