| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein HMX3, Homeobox protein H6 family member 3, Homeobox protein Nkx-51, Hmx3, Nkx-51, Nkx5-1 |
| Entrez GeneID | 15373 |
| WB Predicted band size | 37.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Hmx3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-224 amino acids from the C-terminal region of mouse Hmx3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RUFY1抗体的3篇文献摘要概述：
1. **文献名称**: *RUFY1 regulates autophagosome formation through interaction with LC3*
**作者**: Tanaka S, et al.
**摘要**: 研究揭示了RUFY1通过与自噬标志蛋白LC3互作，调控自噬体形成的分子机制。实验中使用RUFY1抗体进行免疫沉淀和免疫荧光验证其在自噬过程中的定位。
2. **文献名称**: *RUFY1 expression correlates with cancer cell migration in colorectal carcinoma*
**作者**: Liu Y, et al.
**摘要**: 研究发现RUFY1在结直肠癌中高表达，并通过Western blot和免疫组化(使用RUFY1抗体)证实其与肿瘤细胞迁移和侵袭能力正相关，提示其作为潜在治疗靶点。
3. **文献名称**: *RUFY1 modulates neuronal polarity by regulating vesicular trafficking*
**作者**: Wang H, et al.
**摘要**: 该文献通过RUFY1抗体标记发现其在神经元轴突导向中的作用，证明RUFY1通过调控Rab5依赖性囊泡运输影响神经元极性发育。
注：以上文献为示例性质，实际引用时需核实具体来源及发表信息。若需真实文献，建议通过PubMed或Google Scholar检索关键词“RUFY1 antibody”或“RUFY1 function”。
The RUFY1 (RUN and FYVE domain-containing 1) antibody is a tool used to study the RUFY1 protein, a member of the RUFY family involved in intracellular trafficking, autophagy, and cell migration. RUFY1 contains a RUN domain, which mediates protein interactions, and a FYVE domain that binds phosphatidylinositol 3-phosphate (PI3P), anchoring it to endosomal membranes. It plays roles in regulating endosomal sorting, lysosomal function, and autophagosome-lysosome fusion, with implications in cellular homeostasis and disease.
Research highlights RUFY1's involvement in pathological processes, including cancer metastasis, neurodegenerative disorders, and immune responses. Its dysregulation has been linked to altered autophagy in Alzheimer’s disease and enhanced invasiveness in cancers. The antibody enables detection of RUFY1 expression levels, subcellular localization, and interaction partners via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation.
Commercially available RUFY1 antibodies are typically raised in rabbits or mice, validated for specificity across human, mouse, and rat models. They serve as critical reagents for exploring RUFY1's mechanistic roles in health and disease, particularly in autophagy-related pathways and membrane trafficking networks. Recent studies also investigate its potential as a biomarker or therapeutic target in conditions like inflammation and metastatic cancers.
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