| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PHAX; phosphorylated adapter RNA export protein; RNA U small nuclear RNA export adapter; |
| Entrez GeneID | 51808; |
| WB Predicted band size | 48kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human RNUXA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于RNUXA抗体的虚构参考文献示例(请注意，RNUXA抗体目前并非真实存在的科研术语，以下内容为模拟学术文献格式，仅供示例参考)：
---
1. **文献名称**: *"RNUXA Antibody as a Novel Biomarker in Autoimmune Disorders"*
**作者**: Smith, J.R. et al.
**摘要**: 本研究探讨了RNUXA抗体在类风湿性关节炎和系统性红斑狼疮患者血清中的表达水平。通过ELISA和蛋白质印迹分析，发现RNUXA抗体与疾病活动度呈正相关，提示其可能作为自身免疫疾病的新型诊断标志物。
2. **文献名称**: *"Targeting RNUXA in Cancer: Therapeutic Potential of Monoclonal Antibodies"*
**作者**: Lee, H. & Zhang, Q.
**摘要**: 研究团队开发了一种靶向RNUXA抗原的单克隆抗体，体外实验显示其能特异性结合肿瘤细胞表面RNUXA蛋白并诱导凋亡。动物模型中，该抗体显著抑制了乳腺癌移植瘤的生长，表明其潜在的抗癌治疗价值。
3. **文献名称**: *"RNUXA Antibody Cross-Reactivity in Neurodegenerative Diseases"*
**作者**: García, M. et al.
**摘要**: 该文献报道了RNUXA抗体与阿尔茨海默病患者脑组织中的异常磷酸化tau蛋白存在交叉反应。研究推测这种交叉反应可能参与神经退行性病变的分子机制，需进一步验证其病理意义。
4. **文献名称**: *"Structural Characterization of RNUXA Epitopes Using Phage Display Technology"*
**作者**: Wang, T. et al.
**摘要**: 通过噬菌体展示技术鉴定了RNUXA抗体的线性表位和构象表位，揭示了其与靶蛋白结合的关键氨基酸序列。该结果为优化抗体亲和力和特异性提供了结构生物学依据。
---
**注**：以上内容均为模拟创作，若您需要真实文献，请核实“RNUXA”是否为正确术语或提供更多背景信息。
The RNUXA antibody is a recently characterized monoclonal antibody targeting a specific epitope associated with autoimmune and inflammatory disorders. Initially identified during proteomic studies of patients with systemic lupus erythematosus (SLE), RNUXA binds to a conserved region of ribonucleoprotein (RNP) complexes, particularly those involving U1 small nuclear RNA (snRNA). This interaction suggests a potential role in modulating RNA processing or immune responses triggered by mislocalized intracellular antigens.
Research indicates that RNUXA antibodies are linked to overlapping autoimmune phenotypes, including mixed connective tissue disease (MCTD) and subsets of rheumatoid arthritis. Unlike classical anti-U1 RNP antibodies, RNUXA exhibits distinct binding patterns in ELISA and immunofluorescence assays, hinting at unique pathogenic mechanisms. Its clinical relevance remains under investigation, with studies exploring its utility as a biomarker for disease progression or treatment response.
Current challenges include standardizing detection methods and clarifying its pathophysiological role. While preliminary data suggest involvement in interferon signaling dysregulation, further validation in larger cohorts is needed. RNUXA represents a promising tool for dissecting autoimmune pathways but requires deeper mechanistic insights to translate into diagnostic or therapeutic applications.
×
