| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EC 3.1.-.-; Elongin A-binding protein 1; EloA-BP1; Transcription elongation factor B polypeptide 3-binding protein 1; |
| Entrez GeneID | 57455; |
| WB Predicted band size | 132kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human REXO1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于REXO1抗体的3篇参考文献及其摘要内容：
1. **文献名称**: "REXO1 is a multifunctional RNA exonuclease with context-dependent roles in transcription and genome stability"
**作者**: Chen et al.
**摘要**: 该研究揭示了REXO1蛋白作为RNA外切酶的多重功能，通过特异性抗体验证其在RNA加工和转录调控中的作用。实验表明，REXO1通过降解特定非编码RNA影响染色质重塑和基因表达，并与癌症中基因组不稳定性相关。
2. **文献名称**: "REXO1 depletion suppresses colorectal cancer progression by modulating Wnt/β-catenin signaling"
**作者**: Wang et al.
**摘要**: 本文利用REXO1抗体进行免疫组化分析，发现结直肠癌组织中REXO1表达显著上调。功能研究表明，REXO1通过调控Wnt/β-catenin信号通路促进肿瘤侵袭，抗体介导的敲低实验证实其作为潜在治疗靶点的价值。
3. **文献名称**: "Antibody-based profiling of REXO1 subcellular localization reveals dynamic shuttling between nucleus and cytoplasm"
**作者**: Martinez-Lage et al.
**摘要**: 通过免疫荧光和Western blot技术结合REXO1特异性抗体，研究揭示了REXO1在细胞核与细胞质间的动态分布，并发现其定位变化与DNA损伤应答相关，提示其在维持基因组完整性中的作用。
(注：上述文献为示例性内容，实际引用时需根据具体研究补充真实文献信息。)
The REXO1 antibody is a research tool designed to detect and study the RNA exonuclease 1 (REXO1) protein, a conserved 3'-5' exonuclease involved in RNA processing and genome maintenance. REXO1. also known as hDIS3L2 or EXO1L2. plays roles in degrading aberrant RNAs, including uridylated precursors, and participates in quality control pathways such as the cytoplasmic DIS3L2-mediated surveillance system. It is implicated in diverse cellular processes, including cell cycle regulation, DNA repair, and viral RNA clearance. Dysregulation of REXO1 has been linked to developmental disorders, cancer, and autoimmune conditions.
The antibody is typically raised in rabbits or mice using immunogenic peptides or recombinant protein fragments, enabling applications like Western blotting, immunofluorescence, and immunoprecipitation. Validation often includes testing specificity via knockout cell lines or siRNA-mediated knockdown. Researchers use REXO1 antibodies to explore its molecular interactions, subcellular localization (predominantly cytoplasmic), and functional roles in diseases. Commercial variants are available from multiple suppliers, with citations in studies focusing on RNA metabolism, viral replication mechanisms, and genomic instability. Its utility extends to both basic research and translational studies aiming to uncover therapeutic targets linked to REXO1-associated pathways.
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