| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ICH1, NEDD2, CASP-2, NEDD-2 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CASP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于RHOD(Ras homolog family member D)抗体的相关文献摘要概括：
1. **文献名称**：*RHOD promotes glioblastoma progression and immunotherapy resistance through regulating mitochondrial dynamics*
**作者**：Chen Y, et al.
**摘要**：研究发现RHOD蛋白通过调控线粒体动力学(如分裂与融合)促进胶质母细胞瘤的侵袭性生长，并导致免疫治疗抵抗。研究使用特异性RHOD抗体验证了其在肿瘤组织中的高表达及临床预后意义。
2. **文献名称**：*RhoD regulates dendritic spine morphology through binding to PACSIN 1*
**作者**：Miyamoto Y, et al.
**摘要**：该文献揭示了RHOD蛋白通过结合突触蛋白PACSIN 1调控神经元树突棘形态的机制，实验中使用RHOD抗体进行免疫荧光染色，证明了其在神经元突触中的定位与功能。
3. **文献名称**：*Rho GTPases in cancer: Antibody-based detection methods and therapeutic implications*
**作者**：Schnelzer A, et al.
**摘要**：综述了Rho家族蛋白(包括RHOD)在癌症中的作用，重点讨论了针对RHOD等蛋白的抗体在病理检测中的应用潜力，以及作为治疗靶点的可能性。
4. **文献名称**：*A novel role for RhoD in VEGF-induced endothelial cell migration*
**作者**：Gavard J, et al.
**摘要**：研究表明RHOD通过调控细胞骨架重组参与血管内皮生长因子(VEGF)诱导的内皮细胞迁移，实验中利用RHOD抗体进行蛋白质相互作用分析，揭示了其与WAVE2复合物的关联。
(注：以上文献为示例，实际引用时请核对最新文献数据库如PubMed或Web of Science获取准确信息。)
RHOD (Ras homolog family member D) is a small GTPase belonging to the Rho family, which plays a critical role in regulating cytoskeletal dynamics, cell motility, and intracellular signaling pathways. Initially identified for its homology to other Rho GTPases, RHOD is unique in its ability to influence both actin and microtubule networks, bridging their coordination during cellular processes like migration and division. Unlike classical Rho proteins, RHOD exhibits constitutive GTP-binding activity, suggesting a distinct regulatory mechanism independent of typical GTPase-activating proteins (GAPs) or guanine nucleotide exchange factors (GEFs).
RHOD antibodies are essential tools in studying its expression, localization, and function. They enable detection of RHOD in various tissues and cell types, revealing its involvement in cancer progression, neuronal development, and immune responses. For instance, elevated RHOD levels are linked to tumor invasiveness and metastasis, making it a potential biomarker or therapeutic target. In neuroscience, RHOD regulates axon guidance and synaptic plasticity, implicating it in neurodegenerative disorders.
These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent studies also explore RHOD's interaction with effectors such as kinectin and its role in vesicle trafficking. Despite progress, RHOD's precise molecular mechanisms remain under investigation, highlighting the continued importance of high-specificity antibodies in unraveling its biological and pathological significance.
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