| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ARHGEF16; ARHGG; GEF16; NBR; Rho guanine exchange factor (GEF) 16 |
| Entrez GeneID | 27237; |
| WB Predicted band size | 80kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from Internal of human ARHGEF16. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ARHGEF16抗体的模拟参考文献示例(请注意，这些文献为虚构，仅作格式参考)：
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1. **文献名称**: *ARHGEF16 Promotes Hepatocellular Carcinoma Invasion by Activating Rac1 Signaling*
**作者**: Li X, Zhang Y, Chen W.
**摘要**: 本研究利用ARHGEF16特异性抗体，通过免疫组化和Western blot分析发现，ARHGEF16在肝癌组织中高表达，并通过激活Rac1信号通路促进肿瘤细胞迁移和侵袭。抗体验证实验表明，ARHGEF16与Rac1的相互作用在肝癌转移中起关键作用。
2. **文献名称**: *Role of ARHGEF16 in Neuronal Polarization and Axon Guidance*
**作者**: Müller S, Schmidt A, Brakebusch C.
**摘要**: 文章通过免疫荧光染色(使用ARHGEF16抗体)在小鼠皮层神经元中揭示了ARHGEF16在轴突导向中的作用。研究表明，ARHGEF16通过调控Cdc42的活性影响微管动力学，从而参与神经元极化的分子机制。
3. **文献名称**: *ARHGEF16 Interacts with β-PIX to Regulate Focal Adhesion Dynamics in Fibroblasts*
**作者**: Gupta R, Garcia-Mata R, Burridge K.
**摘要**: 利用ARHGEF16抗体进行共免疫沉淀实验，研究发现ARHGEF16与β-PIX形成复合物，共同调控成纤维细胞黏着斑的组装与分解，影响细胞迁移能力。敲低ARHGEF16导致细胞铺展和运动能力显著下降。
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**备注**：以上文献为示例性内容，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实发表的论文。若需具体文献支持，建议使用关键词“ARHGEF16 antibody”、“ARHGEF16 function”结合研究领域(如癌症、神经生物学)进一步筛选。
The ARHGEF16 antibody is a tool used to detect and study the ARHGEF16 protein, a member of the Rho guanine nucleotide exchange factor (GEF) family. ARHGEF16. also known as Ephexin-like or NBR-L, regulates Rho GTPases—key signaling molecules involved in cytoskeletal dynamics, cell migration, and polarity. It activates RhoA and Cdc42 by promoting the exchange of GDP for GTP, thereby influencing processes like neurite outgrowth, immune cell trafficking, and cancer cell invasion. The antibody is commonly employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to localize ARHGEF16 in tissues or cultured cells, assess its expression levels, or investigate its interaction partners.
Research on ARHGEF16 has linked it to neurological disorders, immune regulation, and tumor metastasis. For example, its role in axon guidance and synaptic plasticity suggests implications in neurodegenerative diseases, while its overexpression in certain cancers correlates with enhanced invasiveness. The antibody’s specificity and validation (e.g., knockout controls, peptide blocking) are critical to ensure accurate results. Commercial ARHGEF16 antibodies are typically raised against specific epitopes, often in rabbit or mouse hosts. Understanding ARHGEF16’s function via such antibodies contributes to deciphering its mechanistic roles in health and disease, potentially aiding therapeutic targeting of Rho signaling pathways.
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