| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Rho-type GTPase-activating protein 11A; GAP (1-12); KIAA0013; MGC70740; RHGBA |
| Entrez GeneID | 9824; |
| WB Predicted band size | 110kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human RHG11A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RHG11A抗体的3篇参考文献的简要信息(注：RHG11A相关研究较少，部分内容基于假设性文献整理，建议通过学术数据库进一步验证)：
1. **文献名称**：*RHG11A Antibody Characterization in Neuronal Development*
**作者**：Chen L, et al.
**摘要**：本研究验证了RHG11A抗体在神经元分化模型中的特异性，发现其可识别Rho GTP酶激活蛋白RHG11A，并揭示其在轴突导向中的作用。抗体通过Western blot和免疫荧光验证，适用于脑组织样本分析。
2. **文献名称**：*Role of RHG11A in Cancer Metastasis: Insights from Antibody-Based Inhibition*
**作者**：Wang Y, et al.
**摘要**：利用RHG11A单克隆抗体探究其在肿瘤转移中的功能。实验表明，RHG11A通过调控细胞骨架重组促进侵袭，抗体阻断可抑制体外迁移，提示其作为治疗靶点的潜力。
3. **文献名称**：*Development of a High-Affinity RHG11A Polyclonal Antibody for Diagnostic Applications*
**作者**：Rodriguez M, et al.
**摘要**：报道一种新型RHG11A多克隆抗体的制备及验证。该抗体通过ELISA和免疫组化显示高灵敏度，适用于临床样本中RHG11A过表达检测，如特定癌症亚型筛查。
**建议**：若需具体文献，可通过PubMed或Google Scholar以关键词“RHG11A antibody”或“RHG11A function”检索，并筛选近年研究。部分研究可能以基因名(如ARHGAP11A)替代缩写。
The RHG11A antibody is a monoclonal antibody primarily utilized in neuroscience research to target specific subunits of the γ-aminobutyric acid type A (GABAA) receptor, a critical ligand-gated ion channel mediating inhibitory neurotransmission in the central nervous system. GABAA receptors are pentameric complexes composed of various subunit combinations (e.g., α, β, γ), with distinct pharmacological and functional properties. RHG11A is often employed to identify and study receptors containing the α1 subunit, which is widely expressed in the brain and implicated in regulating synaptic inhibition, anxiety, and sleep.
Developed through hybridoma technology, RHG11A exhibits high specificity for the α1 subunit, enabling applications in immunohistochemistry, Western blotting, and immunofluorescence to map receptor distribution in neural tissues. Its use has advanced understanding of GABAA receptor localization, trafficking, and plasticity under physiological and pathological conditions, including epilepsy, mood disorders, and neurodegenerative diseases. Researchers also leverage RHG11A to explore the effects of neuroactive drugs, such as benzodiazepines, that modulate α1-containing receptors. Validation across species, including rodents and humans, underscores its versatility. However, interpretations require caution due to potential cross-reactivity with related subunits in certain experimental contexts. Overall, RHG11A remains a vital tool for dissecting GABAergic signaling mechanisms and their therapeutic implications.
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