| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ret finger protein-like 4A; RING finger protein 210; RFPL4A; RFPL4; RNF210 |
| Entrez GeneID | 342931; |
| WB Predicted band size | 42kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human RFPL4A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于RFPL4A抗体的3篇参考文献示例(注：以下内容为模拟虚构，实际文献需通过学术数据库核实)：
---
1. **文献名称**: *"Characterization of RFPL4A as a cell cycle-regulated protein through specific antibody development"*
**作者**: Smith J, et al. (2018)
**摘要**: 本研究开发了一种针对RFPL4A蛋白的多克隆抗体，通过Western blot和免疫荧光验证其特异性，发现RFPL4A在细胞周期G1/S期转换中表达上调，提示其在细胞增殖调控中的潜在作用。
2. **文献名称**: *"RFPL4A antibody reveals differential expression in human tumor tissues"*
**作者**: Zhang L, et al. (2020)
**摘要**: 利用商业化RFPL4A单克隆抗体，作者分析了多种癌症组织样本，发现RFPL4A在乳腺癌和结直肠癌中显著高表达，并与患者预后不良相关，为肿瘤标志物研究提供了新方向。
3. **文献名称**: *"Interaction of RFPL4A with DNA repair machinery: Evidence from co-immunoprecipitation assays"*
**作者**: Lee S, et al. (2019)
**摘要**: 通过RFPL4A特异性抗体进行免疫共沉淀实验，鉴定出RFPL4A与BRCA1、RAD51等DNA修复蛋白存在相互作用，提示其在基因组稳定性维持中的功能。
---
**备注**：实际研究中建议通过PubMed、Web of Science等平台以“RFPL4A antibody”为关键词检索最新文献，或参考抗体供应商(如Abcam、CST)产品页引用的论文。
The RFPL4A (Ret Finger Protein Like 4A) antibody targets a protein encoded by the *RFPL4A* gene, which belongs to the RFP (Ret finger protein) family. These proteins are characterized by a conserved RING finger domain, often associated with E3 ubiquitin ligase activity, suggesting roles in protein ubiquitination and degradation. RFPL4A is primarily expressed in the testes and is implicated in germ cell development, particularly during meiosis and spermatogenesis. Studies suggest it may interact with proteins involved in DNA repair or chromatin remodeling, though its precise molecular mechanisms remain under investigation.
Antibodies against RFPL4A are used to study its expression patterns, subcellular localization, and interactions in reproductive biology and disease contexts. In research, RFPL4A antibodies have been employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore its role in fertility and potential links to male infertility. Aberrant RFPL4A expression has also been observed in certain cancers, prompting investigations into its oncogenic or tumor-suppressive functions. Commercially available antibodies are typically raised in rabbits or mice, with validation data including reactivity in human or mouse tissues. Researchers should verify specificity using knockout controls, as cross-reactivity with other RFP family members may occur. Ongoing studies aim to clarify its regulatory networks and therapeutic relevance.
×
