| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TF3C-gamma; TF3C3; TFIIIC 102 kDa subunit; TFIIIC102; TFIIICgamma |
| Entrez GeneID | 9330; |
| WB Predicted band size | 101kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human TF3C3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于TF3C3抗体的虚构参考文献示例(基于常见文献结构模拟，非真实文献)：
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1. **文献名称**: "TF3C3 Antibody Reveals Its Role in Transcriptional Regulation of Cancer Pathways"
**作者**: Smith, A.B., et al.
**摘要**: 本研究利用TF3C3特异性抗体，通过免疫沉淀和ChIP-seq技术，发现TF3C3在多种癌症细胞中通过与RNA聚合酶III复合体结合，调控非编码RNA的转录，促进肿瘤细胞增殖。该抗体为癌症机制研究提供了工具。
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2. **文献名称**: "Development of a High-Affinity Monoclonal Antibody Against Human TF3C3 for Functional Studies"
**作者**: Zhang, L., et al.
**摘要**: 文章报道了一种新型TF3C3单克隆抗体的制备及验证，通过ELISA和免疫荧光证实其高特异性。该抗体成功用于研究TF3C3在细胞核内的定位及其与DNA损伤修复通路蛋白的相互作用。
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3. **文献名称**: "TF3C3 as a Diagnostic Marker: Validation via Antibody-Based Assays in Neurological Disorders"
**作者**: Johnson, R.K., et al.
**摘要**: 研究使用TF3C3抗体在阿尔茨海默病患者脑脊液样本中检测到异常高表达的TF3C3蛋白，提示其可能作为神经退行性疾病的潜在生物标志物，并探讨了其与tau蛋白病理的相关性。
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4. **文献名称**: "Structural Insights into TF3C3 Complex Assembly Using Epitope-Specific Antibodies"
**作者**: Tanaka, M., et al.
**摘要**: 通过TF3C3抗体介导的冷冻电镜技术，揭示了TF3C3蛋白复合体的三维结构及其动态组装机制，为靶向该复合体的药物设计提供了结构基础。
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注：以上文献为模拟生成，实际研究中请根据具体需求检索真实数据库(如PubMed)。
The TFIIIC3 antibody targets the TFIIIC3 (Transcription Factor III C subunit 3) protein, a critical component of the TFIIIC complex in eukaryotic transcription. The TFIIIC complex is essential for RNA polymerase III (Pol III)-mediated transcription of small non-coding RNAs, including tRNAs, 5S rRNA, and other small RNAs. Specifically, TFIIIC3. along with other subunits (TFIIIC1. TFIIIC2. etc.), facilitates promoter recognition and assembly of the transcription machinery by binding to conserved B-box elements in target genes. It also plays a role in chromatin remodeling and transcriptional regulation beyond Pol III-dependent processes, interacting with histone modifiers and other transcription factors.
Antibodies against TFIIIC3 are widely used in research to investigate Pol III-dependent transcription mechanisms, gene regulation in cancer (where Pol III activity is often dysregulated), and cellular stress responses. They enable techniques like chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence to study TFIIIC3 localization, expression levels, and interactions. Dysregulation of TFIIIC3 has been implicated in oncogenesis, neurological disorders, and viral infections, making it a potential biomarker or therapeutic target. The antibody's specificity and reliability depend on epitope conservation across species and validation in functional assays, ensuring its utility in both basic and translational studies.
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