| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | T-box transcription factor TBX10; T-box protein 10; TBX10; TBX7; |
| Entrez GeneID | 347853; |
| WB Predicted band size | 43kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human TBX10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TBX1抗体的3篇参考文献示例(内容基于模拟学术文献，仅供参考)：
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1. **文献名称**：*TBX1 regulates cardiac progenitor cell migration via Wnt signaling*
**作者**：Xu, H., et al.
**摘要**：本研究通过免疫组化和小鼠模型探究TBX1在心脏发育中的作用，利用TBX1抗体检测胚胎期心脏神经嵴细胞中的蛋白定位，发现TBX1通过调控Wnt通路影响细胞迁移，为先天性心脏病机制提供新见解。
2. **文献名称**：*Characterization of TBX1 antibody specificity in DiGeorge syndrome models*
**作者**：Jerome, L.A., & Puechberty, J.
**摘要**：通过Western blot和免疫荧光技术评估商业TBX1抗体的特异性，证实其在人类细胞系和小鼠组织中的有效性，并应用于DiGeorge综合征患者样本分析，揭示TBX1蛋白表达缺失与表型的相关性。
3. **文献名称**：*Tbx1 and neural crest development in zebrafish*
**作者**：Piotrowski, T., et al.
**摘要**：在斑马鱼模型中利用TBX1抗体进行全胚胎免疫染色，揭示Tbx1在咽弓和神经嵴细胞分化中的动态表达模式，证实其与颅面部发育异常的关联。
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注：以上文献信息为示例性模拟，实际引用请通过学术数据库(如PubMed、Web of Science)核实。
**Background of TBX1 Antibody**
The TBX1 antibody is a tool used to detect TBX1. a transcription factor encoded by the *TBX1* gene, which belongs to the T-box family of genes critical for embryonic development. TBX1 plays a pivotal role in regulating the formation of pharyngeal arches, cardiac outflow tract, and craniofacial structures during early development. It is particularly associated with DiGeorge syndrome (22q11.2 deletion syndrome), where haploinsufficiency of TBX1 contributes to phenotypes such as congenital heart defects, thymic hypoplasia, and craniofacial abnormalities.
TBX1 antibodies are widely utilized in research to study protein expression, localization, and function in developmental biology. They are employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess TBX1 levels in tissues or cell lines, often in models of developmental disorders or gene knockout studies. These antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the TBX1 protein. Validation includes testing for specificity via knockout controls or siRNA-mediated knockdown.
Research involving TBX1 antibodies has advanced understanding of its role in signaling pathways (e.g., FGF, BMP) and its interaction with other developmental regulators. Such studies are crucial for elucidating mechanisms underlying congenital defects and exploring potential therapeutic strategies.
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