Rabbit Polyclonal LMX1B Antibody

The LMX1B antibody is a crucial tool in biomedical research, targeting the LMX1B protein (LIM homeobox transcription factor 1B), a key regulator in embryonic development. LMX1B belongs to the LIM-homeodomain transcription factor family, characterized by two LIM domains (zinc-binding motifs) and a DNA-binding homeodomain. It plays vital roles in dorsoventral patterning, limb development, and the differentiation of dopaminergic neurons in the midbrain. Mutations in the LMX1B gene are linked to Nail-Patella syndrome, a rare autosomal dominant disorder affecting nails, skeletal structures, kidneys, and eyes. Researchers use LMX1B antibodies to study its expression patterns, interactions, and regulatory mechanisms in developmental biology, neurodegenerative diseases (e.g., Parkinson’s disease, due to its role in dopaminergic neuron survival), and renal pathologies. These antibodies are widely applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize protein localization and quantify expression levels in tissues or cell lines. Their specificity and reliability make them essential for exploring LMX1B’s contributions to disease pathways and potential therapeutic targets.