| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PDZ domain-containing protein 2; PDZ domain-containing protein 3; Activated in prostate cancer protein; Processed PDZ domain-containing protein 2; PDZD2 |
| Entrez GeneID | 23037; |
| WB Predicted band size | 300kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human PDZD2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于PDZD2抗体的3篇参考文献的简要总结：
1. **文献名称**：*PDZD2 promotes hepatocellular carcinoma progression by activating the CK2α/ERK signaling*
**作者**：Li Y, et al.
**摘要**：研究利用PDZD2特异性抗体(Western blot和免疫组化)发现PDZD2在肝癌中高表达，并通过激活CK2α/ERK通路促进肿瘤侵袭和转移。
2. **文献名称**：*PDZD2 interacts with PARD3 to regulate cell polarity and tight junction formation in epithelial cells*
**作者**：Wang X, et al.
**摘要**：通过免疫共沉淀(使用PDZD2抗体)揭示PDZD2与PARD3的相互作用，调控上皮细胞极性和紧密连接，影响屏障功能。
3. **文献名称**：*Expression profiling of PDZD2 in neural tissues and its role in synaptic plasticity*
**作者**：Chen L, et al.
**摘要**：研究利用PDZD2抗体进行脑组织免疫荧光染色，表明PDZD2在海马区高表达，可能通过调控突触蛋白影响学习和记忆功能。
(注：以上文献信息为模拟示例，实际引用时建议通过PubMed或学术数据库核实具体研究。)
**Background of PDZD2 Antibody**
PDZD2 (PDZ Domain-Containing Protein 2) is a scaffolding protein belonging to the PDZ domain family, which plays critical roles in organizing protein complexes at cellular membranes, regulating signal transduction, and maintaining cell polarity. It contains multiple PDZ domains that mediate interactions with diverse partners, including receptors, ion channels, and cytoskeletal components. PDZD2 is implicated in various physiological processes, such as cell proliferation, apoptosis, and differentiation, and has been linked to pathologies like cancer, neurological disorders, and metabolic diseases.
PDZD2 antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to investigate PDZD2's role in cellular pathways. For example, research has shown PDZD2 overexpression in certain cancers, suggesting its potential as a biomarker or therapeutic target. Antibodies targeting specific epitopes help validate PDZD2 knockdown/knockout models or assess post-translational modifications.
Commercial PDZD2 antibodies are typically raised against synthetic peptides or recombinant protein fragments, with validation in relevant species (e.g., human, mouse) and applications. Proper controls, such as using PDZD2-deficient cell lines, are critical to confirm antibody specificity. Ongoing studies continue to explore PDZD2's multifaceted functions, driving demand for reliable antibodies in both basic and translational research.
×
