| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CIN5; HH1; SCN5A; Sodium channel protein; cardiac muscle alpha-subunit |
| Entrez GeneID | 6331; |
| WB Predicted band size | 230kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human sodium channel. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Sodium Channel-pan抗体的3篇参考文献(示例基于虚构内容，实际文献需通过数据库检索)：
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1. **文献名称**: *"A pan-specific sodium channel antibody for detecting voltage-gated Na+ channels across tissues"*
**作者**: Smith A, et al.
**摘要**: 该研究开发了一种新型泛钠通道(pan-Sodium Channel)抗体，可识别多种电压门控钠通道亚型(Nav1.1-Nav1.9)，通过Western blot和免疫组化验证其在脑、心脏及骨骼肌组织中的广泛适用性，为跨组织钠通道表达研究提供工具。
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2. **文献名称**: *"Characterization of a pan-sodium channel monoclonal antibody in neuropathic pain models"*
**作者**: Lee B, et al.
**摘要**: 作者利用单克隆泛钠通道抗体探究神经病理性疼痛模型中钠通道亚型的表达变化，发现该抗体可同时结合Nav1.3、Nav1.7和Nav1.9.并揭示其在背根神经节中的共定位，支持其在疼痛机制研究中的应用。
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3. **文献名称**: *"Validation of a commercial pan-sodium channel antibody for immunohistochemical applications"*
**作者**: Chen C, et al.
**摘要**: 本研究验证了一种商品化泛钠通道抗体在福尔马林固定石蜡包埋组织中的性能，证明其适用于多种癌症组织(如乳腺癌、胶质瘤)中钠通道的泛表达检测，提示钠通道异常表达与肿瘤进展相关。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词：**"pan-sodium channel antibody"** 或 **"voltage-gated sodium channel pan-specific"**，筛选实验类研究论文。
Sodium channel-pan antibodies are essential tools in neuroscience, cardiovascular research, and cellular physiology for studying voltage-gated sodium channels (VGSCs), which are critical for action potential generation and electrical signaling. These pan-specific antibodies recognize conserved epitopes across multiple sodium channel subtypes (Nav1.1-Nav1.9 and Nax), unlike subtype-specific antibodies. This broad reactivity makes them particularly useful for detecting unknown or multiple isoforms in tissues or cell lines without prior subtype characterization.
VGSCs consist of a pore-forming α-subunit with four homologous domains, each containing six transmembrane segments. Pan antibodies often target conserved intracellular regions, such as loop sequences between domains III-IV, enabling cross-reactivity. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to localize sodium channels in neurons, cardiomyocytes, and excitable cells.
These antibodies have contributed to research on channelopathies, including epilepsy, arrhythmias, and neuropathic pain, as well as cancer studies where aberrant sodium channel expression correlates with metastasis. However, users must validate target specificity, as sequence conservation among subtypes can lead to unintended cross-reactivity. Species reactivity (e.g., human, mouse, rat) and application-specific optimization are critical considerations. Overall, sodium channel-pan antibodies provide a versatile approach for initial screening and comparative studies of sodium channel distribution and expression across biological systems.
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