Rabbit Polyclonal RetinoidXReceptorγ Antibody

The Retinoid X Receptor gamma (RXRγ), a member of the nuclear receptor superfamily, functions as a ligand-dependent transcription factor regulating gene expression by forming heterodimers with other nuclear receptors (e.g., RAR, PPAR, LXR). It plays critical roles in cellular differentiation, metabolic homeostasis, and neurodevelopment. RXRγ is particularly abundant in the central nervous system, skeletal muscle, and adipose tissue, with emerging links to neurodegenerative disorders, metabolic syndromes, and cancer. Antibodies targeting RXRγ are essential tools for studying its expression patterns, protein-protein interactions, and downstream signaling mechanisms. They enable techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to map tissue-specific localization, DNA-binding activity, and post-translational modifications. Recent studies highlight RXRγ's involvement in oligodendrocyte maturation (via cooperation with thyroid hormone receptors) and insulin sensitivity regulation (through PPARγ crosstalk). Its antibody has been instrumental in characterizing RXRγ knockout models, revealing compensatory roles in lipid metabolism and neuroprotection. Validation parameters, including specificity (via knockout controls), cross-reactivity checks, and application-specific optimization, are critical due to structural similarities across RXR isoforms (α, β, γ). Research using these antibodies continues to uncover therapeutic targets for conditions like Alzheimer’s disease, multiple sclerosis, and type 2 diabetes.