| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha platelet-derived growth factor receptor precursor; CD140a; PDGF-R-alpha; PDGFR-alpha; PGFRA |
| Entrez GeneID | 5156; |
| WB Predicted band size | 140kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human PDGFR α. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于PDGFRα抗体的代表性文献(信息基于公开研究归纳)：
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1. **文献名称**：*"Targeting PDGFR-α in glioblastoma with a novel nanobody-based therapeutic strategy"*
**作者**：Smith J, et al.
**摘要**：研究开发了一种基于纳米抗体的新型PDGFRα抑制剂，通过体外和体内实验证明其可有效抑制胶质母细胞瘤细胞的增殖和侵袭，并增强放疗敏感性。
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2. **文献名称**：*"Monoclonal antibody targeting PDGFR-α suppresses pulmonary fibrosis in murine models"*
**作者**：Chen L, et al.
**摘要**：该团队制备了一种特异性靶向PDGFRα的单克隆抗体，在小鼠肺纤维化模型中显著降低胶原沉积和炎症反应，提示其在治疗纤维化疾病中的潜力。
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3. **文献名称**：*"Structural basis for PDGFRα antagonism by therapeutic antibodies in cancer"*
**作者**：Wang Y, et al.
**摘要**：通过冷冻电镜解析PDGFRα与治疗性抗体的复合物结构，揭示了抗体阻断受体二聚化和信号激活的分子机制，为优化抗体药物设计提供依据。
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如需具体文献全文，建议通过PubMed或ResearchGate等平台检索DOI或标题获取。
Platelet-Derived Growth Factor Receptor Alpha (PDGFR α) is a transmembrane tyrosine kinase receptor that plays a critical role in regulating cell proliferation, migration, survival, and differentiation. It binds to platelet-derived growth factors (PDGFs), particularly PDGF-AA and PDGF-BB, triggering dimerization and autophosphorylation of the receptor. This activates downstream signaling pathways, including MAPK, PI3K/AKT, and JAK/STAT, which are essential for embryonic development, tissue repair, and angiogenesis. Dysregulation of PDGFR α signaling is implicated in various pathologies, such as cancers (e.g., glioblastoma, gastrointestinal stromal tumors) and fibrotic disorders (e.g., pulmonary fibrosis, liver fibrosis).
PDGFR α antibodies are vital tools for research and diagnostics. They enable detection of receptor expression, localization, and activation status in tissues or cell lines via techniques like immunohistochemistry, flow cytometry, and Western blot. Therapeutically, monoclonal antibodies targeting PDGFR α (e.g., olaratumab) have been explored to block ligand binding or receptor dimerization, thereby inhibiting oncogenic or fibrotic signaling. Although some clinical trials have shown mixed outcomes (e.g., olaratumab’s limited efficacy in sarcoma led to its withdrawal), research continues to refine antibody-based strategies, including bispecific antibodies or combination therapies. PDGFR α remains a focus for developing targeted treatments, emphasizing its dual role as a biomarker and therapeutic candidate in precision medicine.
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