| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MART-1; MART1; melan-A; MELAN A; MELANOMA ANTIGEN RECOGNIZED BY T CELLS 1 |
| Entrez GeneID | 2315; |
| WB Predicted band size | 15kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from human MART-1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3条关于MART-1抗体的代表性文献摘要(信息基于公开研究整理，具体文献需核实原文)：
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1. **文献名称**：*MART-1: A Novel Melanoma Antigen Recognized by T Cells*
**作者**：Kawakami, Y. et al. (1994)
**摘要**：首次鉴定了MART-1(Melanoma Antigen Recognized by T Cells-1)作为黑色素瘤特异性抗原，被HLA-A2限制性细胞毒性T淋巴细胞识别，为开发MART-1抗体奠定基础。
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2. **文献名称**：*Monoclonal Antibody A103: A Marker for Melanocytic Differentiation*
**作者**：Jungbluth, A.A. et al. (1998)
**摘要**：报道了单克隆抗体A103对MART-1抗原的特异性识别，验证其在石蜡包埋组织中的敏感性(>85%黑色素瘤阳性)，强调其作为黑色素细胞分化标志物的诊断价值。
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3. **文献名称**：*Comparison of Antibodies for Immunohistochemistry in Melanoma Diagnosis*
**作者**：Busam, K.J. et al. (2001)
**摘要**：系统比较了MART-1抗体(如A103和M2-7C10)与HMB-45等抗体的性能，指出MART-1抗体在检测转移性黑色素瘤中敏感性更高，但需与其他标志物联用以提高特异性。
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**提示**：建议通过PubMed或Google Scholar检索上述作者及关键词获取原文。若需最新研究，可补充检索近5年文献(如纳米抗体或新型检测技术应用)。
The MART-1 (Melanoma Antigen Recognized by T cells 1) antibody is a widely used diagnostic tool in pathology, primarily targeting the MART-1 protein encoded by the *MLANA* gene. Discovered in the 1990s, MART-1 is a melanocyte differentiation antigen expressed in normal pigment-producing cells (melanocytes) and their neoplastic counterparts, such as melanoma cells. Its name reflects its initial identification as a target of cytotoxic T lymphocytes in melanoma patients, highlighting its role in immune recognition.
In diagnostic applications, the MART-1 antibody serves as a sensitive immunohistochemical marker for melanocytic lesions. It aids in distinguishing melanoma from other malignancies, particularly in cases with ambiguous morphology. Compared to other melanoma markers like S100 (less specific) or HMB-45 (less sensitive in metastatic melanoma), MART-1 demonstrates high specificity for melanocytic lineage, though it may also stain non-melanoma tissues like adrenal cortical cells or retinal pigment epithelium.
Clinically, MART-1 antibody-based staining supports the classification of primary and metastatic melanomas, including amelanotic variants. Its utility extends to research, where it helps study melanocyte biology, tumor progression, and immunotherapy targets. Despite advances in molecular diagnostics, MART-1 remains a cornerstone in melanoma pathology due to its reliability and cost-effectiveness. However, interpretation requires contextual integration with histology and complementary markers to avoid diagnostic pitfalls.
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