| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GPRC1H; MGLUR8; mGlu8; GLUTAMATE RECEPTOR; METABOTROPIC |
| Entrez GeneID | 2918; |
| WB Predicted band size | 100kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human GluR8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GluR8抗体的3篇参考文献示例(注：文献信息为模拟示例，实际引用请核实原始文献)：
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1. **文献名称**：*Distribution of AMPA receptor subunits (GluR1-4 and GluR8) in the rat hippocampus*
**作者**：Petralia RS, et al.
**摘要**：本研究通过免疫组化分析GluR8在大鼠海马中的分布，发现其高表达于CA3区突触，提示其在调节谷氨酸能突触传递中的特异性作用。
2. **文献名称**：*Characterization of a polyclonal antibody against the GluR8 subunit of AMPA receptors*
**作者**：Bettler B, et al.
**摘要**：报道了一种特异性识别GluR8的多克隆抗体的开发，验证其在Western blot和免疫荧光中的有效性，并证明其不与其他AMPA受体亚型交叉反应。
3. **文献名称**：*GluR8 deficiency increases seizure susceptibility in mice*
**作者**：Lippiello P, et al.
**摘要**：利用GluR8敲除小鼠模型，结合抗体标记技术，发现GluR8缺失导致神经元兴奋性升高，可能与颞叶癫痫的病理机制相关。
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**注意**：以上文献信息为基于领域知识的模拟，实际研究请参考PubMed或Web of Science等数据库的最新文献。
The GluR8 antibody is a specialized tool used to detect and study the glutamate receptor 8 (GluR8), a subunit of the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor family. AMPA receptors are critical for fast excitatory synaptic transmission in the central nervous system, mediating neuronal communication and synaptic plasticity. GluR8. encoded by the *GRIA8* gene, is less commonly expressed compared to other AMPA subunits (e.g., GluR1-4) and exhibits distinct regional distribution, with higher levels observed in the cerebellum, hippocampus, and certain cortical areas. Its functional role remains under investigation but may involve modulating synaptic strength and network excitability.
GluR8 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides derived from specific epitopes of the receptor. These antibodies enable researchers to visualize GluR8 expression via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. They are essential for exploring GluR8's involvement in neurological processes, including learning, memory, and pathological conditions like epilepsy or neurodegenerative diseases. Validation of antibody specificity is crucial, often achieved through knockout controls or siRNA knockdown. Understanding GluR8 dynamics contributes to broader insights into AMPA receptor diversity and their implications in brain function and disease.
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