| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Component II; GAS; GAST; gastrin precursor; |
| Entrez GeneID | 2520; |
| WB Predicted band size | 12kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from human Gastrin. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于Gastrin抗体的代表性文献摘要(基于公开知识库信息，非实时数据)：
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1. **文献名称**: "Gastrin antibodies in the diagnosis of gastrinoma"
**作者**: Waldum HL, et al.
**摘要**: 研究探讨了胃泌素抗体在诊断胃泌素瘤(一种分泌胃泌素的神经内分泌肿瘤)中的临床价值。通过免疫组织化学法检测肿瘤组织中胃泌素抗体的表达，发现其敏感性和特异性较高，可作为辅助诊断工具。
2. **文献名称**: "Autoantibodies to gastrin in autoimmune gastritis"
**作者**: Toh BH, et al.
**摘要**: 该文献发现部分自身免疫性胃炎患者血清中存在针对胃泌素的自身抗体。这些抗体可能通过干扰胃泌素信号通路，导致胃酸分泌减少和胃黏膜萎缩，为疾病机制研究提供了新方向。
3. **文献名称**: "Monoclonal antibodies targeting gastrin for cancer therapy"
**作者**: Smith JP, Watson JD.
**摘要**: 研究开发了靶向胃泌素的单克隆抗体，并在动物模型中验证其抑制胃泌素促肿瘤生长的作用。结果显示，抗体可阻断胃泌素与其受体结合，抑制结直肠癌和胰腺癌的进展。
4. **文献名称**: "Comparative analysis of gastrin antibody detection methods"
**作者**: Burkitt MD, et al.
**摘要**: 对比了ELISA、免疫荧光和Western blot等多种胃泌素抗体检测技术的优缺点，提出标准化检测流程的建议，以提高实验结果的可重复性和临床适用性。
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注：以上为示例性内容，实际文献需通过学术数据库(如PubMed)检索最新研究。
Gastrin antibodies are autoantibodies targeting gastrin, a peptide hormone primarily produced by G-cells in the stomach antrum and duodenum. Gastrin stimulates gastric acid secretion and mucosal growth. The presence of gastrin antibodies is linked to autoimmune gastritis, a chronic inflammatory condition where the immune system attacks gastric parietal cells and intrinsic factor, impairing acid production and nutrient absorption (e.g., vitamin B12). These antibodies are classified into two types: Type I binds to gastrin directly, while Type II targets gastrin-producing G-cells, potentially disrupting hormone regulation.
Clinically, gastrin antibodies are associated with autoimmune disorders like pernicious anemia and atrophic gastritis, which may progress to gastric cancer if untreated. Their detection, often via ELISA or immunofluorescence, aids in diagnosing autoimmune gastrointestinal pathologies, differentiating them from other gastritis causes (e.g., *H. pylori* infection). Research also explores their role in modulating gastrin-related pathways, such as tumor growth in gastrointestinal cancers, though mechanisms remain unclear.
While not routinely tested, gastrin antibodies contribute to understanding autoimmune-mediated gastric dysfunction. Their presence may correlate with disease severity, offering insights into personalized treatment strategies. However, further studies are needed to clarify their pathogenic role and therapeutic potential, including antibody-targeted interventions.
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