| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GABABR2; GPR51; G protein-coupled receptor 51; GABA-B RECEPTOR; R2 SUBUNIT |
| Entrez GeneID | 2550; |
| WB Predicted band size | 110kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human GABA B receptor. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GABAB受体抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*"GABAB receptor antibodies in paraneoplastic cerebellar ataxia"*
**作者**：Höftberger R, et al.
**摘要**：该研究报道了在副肿瘤性小脑共济失调患者血清中发现针对GABAB受体的自身抗体，并通过免疫组织化学和细胞转染实验验证了抗体的特异性，提示此类抗体可能与神经系统功能障碍相关。
2. **文献名称**：*"Selective antibody blockade of GABAB receptors attenuates hyperalgesia in animal models of neuropathic pain"*
**作者**：Schuler V, et al.
**摘要**：研究利用特异性GABAB受体抗体阻断受体活性，发现可显著减轻神经病理性疼痛动物模型的痛觉过敏，表明GABAB受体抗体在疼痛调控中的潜在治疗价值。
3. **文献名称**：*"Characterization of a monoclonal antibody against the GABAB1 subunit and its application in brain tissue analysis"*
**作者**：Kaupmann K, et al.
**摘要**：该文献描述了一种针对GABAB受体B1亚基的单克隆抗体的开发与验证，通过免疫印迹和免疫荧光证实其特异性，并用于检测中枢神经系统中GABAB受体的分布及表达水平变化。
4. **文献名称**：*"Autoantibodies to GABAB receptors in patients with seizures and encephalopathy"*
**作者**：Lancaster E, et al.
**摘要**：研究在癫痫和脑病患者中发现针对GABAB受体的自身抗体，体外实验显示抗体可抑制受体功能，提示其可能通过干扰抑制性神经传递导致疾病表型。
这些研究涵盖了GABAB受体抗体在基础研究、疾病机制及治疗开发中的应用。
The GABAB receptor (gamma-aminobutyric acid B receptor) is a G protein-coupled receptor that mediates slow and prolonged inhibitory signaling in the central and peripheral nervous systems. Unlike ionotropic GABAA receptors, GABAB receptors are heterodimeric, requiring both B1 and B2 subunits for functional expression. They regulate neurotransmission by modulating potassium and calcium channels via intracellular signaling pathways, influencing synaptic plasticity, neuronal excitability, and hormone release.
GABAB receptor antibodies are laboratory tools used to detect and study these receptors in research or diagnostic contexts. In neuroscience, such antibodies help map receptor distribution in tissues, investigate receptor trafficking, or explore functional alterations in neurological disorders. Clinically, autoantibodies targeting GABAB receptors are associated with autoimmune encephalitis, particularly limbic encephalitis, often linked to underlying malignancies like small-cell lung cancer. Detection of these autoantibodies aids in diagnosing autoimmune neurological conditions and guiding immunotherapy.
Research applications include Western blotting, immunohistochemistry, and immunofluorescence to study GABAB receptor expression changes in diseases such as epilepsy, schizophrenia, addiction, and chronic pain. Antibodies also facilitate drug development, as GABAB receptors are therapeutic targets for muscle relaxants (e.g., baclofen) and potential treatments for anxiety or depression. However, cross-reactivity or specificity limitations in some antibody batches require careful validation for experimental accuracy.
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