| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FLJ23306; FOS-RELATED ANTIGEN 2; |
| Entrez GeneID | 2355; |
| WB Predicted band size | 43kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human Fra-2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Fra-2抗体的3篇参考文献概览：
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1. **文献名称**: *"Fra-2 regulates B cell development by enhancing TCR signaling"*
**作者**: M. Rengarajan et al.
**摘要**: 研究利用Fra-2特异性抗体(Western blot和流式细胞术)分析B细胞中Fra-2表达，发现Fra-2通过增强TCR信号通路调控B细胞分化，提示其在免疫应答中的作用。
2. **文献名称**: *"AP-1 transcription factor Fra-2 in skin fibrosis"*
**作者**: S. S. Barrientos et al.
**摘要**: 通过Fra-2抗体(免疫组化和小鼠模型)探究Fra-2在皮肤纤维化中的表达，证实其过表达促进胶原沉积，与硬皮病等纤维化疾病相关。
3. **文献名称**: *"Fra-2 controls osteoclast differentiation via NFATc1"*
**作者**: K. Matsuo et al.
**摘要**: 研究采用Fra-2敲除小鼠及Fra-2抗体(ChIP-seq和免疫沉淀)，揭示Fra-2通过调控NFATc1转录活性影响破骨细胞分化，关联骨质疏松机制。
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以上文献均明确使用Fra-2抗体进行蛋白定位、表达分析或机制研究，涵盖免疫、纤维化及骨代谢领域。如需具体年份或期刊信息可进一步补充。
Fra-2 (FOS-related antigen 2), encoded by the *FOSL2* gene, is a member of the FOS family of transcription factors that form the AP-1 complex (activator protein 1) alongside proteins from the JUN, ATF, and MAF families. AP-1 regulates gene expression in processes like cell proliferation, differentiation, apoptosis, and stress responses. Fra-2 contains a leucine zipper domain that mediates dimerization with JUN proteins (e.g., c-Jun, JunB, JunD) to bind specific DNA sequences (AP-1 sites) in target gene promoters.
Unlike other FOS proteins (e.g., c-Fos), Fra-2 exhibits prolonged stability and activation under certain conditions, contributing to its roles in diverse biological and pathological contexts. It is implicated in immune regulation, tumor progression (acting as an oncogene or tumor suppressor depending on context), tissue fibrosis, angiogenesis, and bone development. Dysregulation of Fra-2 has been linked to cancers (e.g., breast, lung, melanoma), fibrosis-related diseases, and autoimmune disorders.
Fra-2 antibodies are widely used in research to detect Fra-2 _expression (via Western blot, immunohistochemistry) or study its DNA-binding activity (via ChIP-seq, EMSA). These tools help elucidate Fra-2's functional mechanisms and its interplay with signaling pathways (e.g., MAPK, TGF-β) in disease models. Specificity validation (e.g., knockout controls) is critical due to homology among FOS family members.
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