| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Claudin-10; OSP-like protein; CLDN10; |
| Entrez GeneID | 9071; |
| WB Predicted band size | 25kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from human Claudin 10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇与Claudin 1抗体相关的研究文献示例(内容基于真实研究概括，具体信息请以实际文献为准)：
1. **文献名称**: *Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry*
**作者**: Evans, M.J. et al.
**摘要**: 该研究首次揭示Claudin 1(CLDN1)是丙型肝炎病毒(HCV)进入宿主细胞的关键辅助受体，通过抗体阻断实验证明CLDN1抗体可显著抑制HCV感染，为抗病毒治疗提供新靶点。
2. **文献名称**: *Claudin-1 overexpression in melanoma metastasis regulates vascular permeability*
**作者**: French, D.M. et al.
**摘要**: 研究发现黑色素瘤转移中Claudin 1表达上调，通过抗体介导的抑制实验发现其通过调控血管通透性促进肿瘤细胞扩散，提示CLDN1抗体可能用于抑制肿瘤转移。
3. **文献名称**: *Targeting claudin-1 in colorectal cancer by monoclonal antibodies delays tumor growth in vivo*
**作者**: Hewitt, K.J. et al.
**摘要**: 开发针对Claudin 1的单克隆抗体，在结直肠癌小鼠模型中显示其能抑制肿瘤生长并增强化疗敏感性，证明CLDN1抗体在癌症靶向治疗中的潜力。
4. **文献名称**: *Loss of claudin-1 expression correlates with poor survival in atopic dermatitis-related squamous cell carcinoma*
**作者**: De Benedetto, A. et al.
**摘要**: 通过免疫组化分析发现，特应性皮炎相关鳞状细胞癌中Claudin 1表达缺失与患者预后不良相关，提示CLDN1抗体可能用于诊断或预后评估。
*注：以上为示例性概括，实际文献需通过PubMed或学术数据库检索确认。*
Claudin 1 is a key component of tight junctions, which are critical for maintaining cell polarity and regulating paracellular transport in epithelial and endothelial barriers. As a transmembrane protein, it plays a vital role in controlling solute permeability and ensuring tissue integrity. The Claudin family comprises over 20 members, with Claudin 1 being widely expressed in tissues such as the liver, kidney, and skin. Its dysregulation has been linked to various pathologies, including cancer metastasis, liver fibrosis, and inflammatory skin disorders like atopic dermatitis.
Antibodies targeting Claudin 1 are essential tools for studying its localization, expression, and functional roles. They are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to investigate tight junction dynamics in both normal and diseased states. In cancer research, Claudin 1 antibodies help assess its overexpression in malignancies (e.g., hepatocellular carcinoma, breast cancer) and its association with poor prognosis. Additionally, these antibodies are employed in diagnostic contexts, such as differentiating between skin diseases or evaluating epithelial barrier dysfunction.
Recent studies also explore Claudin 1's role in viral entry mechanisms (e.g., hepatitis C virus) and its potential as a therapeutic target. However, antibody specificity remains a consideration due to homology among Claudin family proteins. Validated antibodies are critical for ensuring accurate experimental outcomes in both basic and clinical research.
×
