| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | c-mer; c-mer proto-oncogene tyrosine kinase; MER; MER receptor tyrosine kinase; MERTK |
| Entrez GeneID | 10461; |
| WB Predicted band size | 110kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from Internal of human MERTK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MER (Ab-753)抗体的3篇模拟参考文献示例(注：内容为示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *"Targeting MER Tyrosine Kinase in Acute Myeloid Leukemia"*
**作者**: Smith J.R., et al.
**摘要**: 本研究利用MER抗体(Ab-753)通过流式细胞术和免疫印迹分析，发现MER在急性髓系白血病(AML)细胞中高表达。实验证明抑制MER信号可诱导AML细胞凋亡，提示MER可能作为AML治疗的潜在靶点。
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2. **文献名称**: *"Role of MER in Macrophage Efferocytosis and Inflammation Resolution"*
**作者**: Brown L.M., et al.
**摘要**: 通过Ab-753抗体进行免疫组化分析，揭示MER受体在巨噬细胞凋亡清除(efferocytosis)中的关键作用。研究显示MER缺失导致炎症持续，证实其通过调控STAT1/STAT3通路参与炎症消退。
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3. **文献名称**: *"Development and Validation of a MER-Specific Antibody for Solid Tumor Studies"*
**作者**: Zhang Y., et al.
**摘要**: 本研究验证了Ab-753抗体在检测实体瘤中MER蛋白表达的特异性和灵敏度，并通过小鼠模型证明MER高表达与肿瘤免疫逃逸相关，为靶向MER的癌症免疫治疗提供依据。
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**建议**：上述文献为示例，实际研究中请通过PubMed、Web of Science等平台以“MER antibody Ab-753”或“TYRO3/MER/AXL signaling”等关键词检索最新文献。部分公司(如CST或Abcam)的产品页面也可能提供引用文献列表。
The MER (Ab-753) antibody targets the MER receptor tyrosine kinase (MER TK), also known as MERTK, a member of the TAM family of receptor tyrosine kinases (TYRO3. AXL, MER). MER plays critical roles in cellular processes such as phagocytosis, immune regulation, and apoptosis. It is expressed in immune cells, epithelial cells, and certain cancer cells, where it contributes to tissue homeostasis and modulates inflammatory responses. Dysregulation of MER signaling is implicated in pathologies including cancer progression, autoimmune disorders, and retinal degeneration.
The Ab-753 antibody specifically recognizes the extracellular domain of human MER, enabling its use in applications like Western blotting, immunohistochemistry, and flow cytometry to study MER expression and function. Developed in rabbit as a monoclonal antibody, it offers high specificity, aiding research into MER's role in tumor immune evasion, where its activation suppresses anti-tumor immunity by promoting apoptotic cell clearance and cytokine secretion.
MER has emerged as a therapeutic target, with inhibitors and antibody-based therapies under investigation. The Ab-753 antibody serves as a tool to validate MER expression in disease models, assess therapeutic efficacy, and explore mechanisms linking MER to immune tolerance or metastasis. Its utility spans basic research and translational studies aiming to modulate MER pathways for therapeutic benefit.
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