| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TOB; Transducer of erbB-2 1; |
| Entrez GeneID | 10140; |
| WB Predicted band size | 40kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human TOB1 around the phosphorylation site of serine 164 (A-V-S(p)-P-T). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TOB1(Ab-164)抗体的3篇参考文献的简要总结(注：文献信息为模拟示例，实际引用需根据具体文献调整)：
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1. **文献名称**: "TOB1通过抑制ERK信号通路调控乳腺癌细胞增殖"
**作者**: Zhang L, et al.
**摘要**: 本研究使用TOB1抗体(Ab-164.购自ABC公司)进行Western blot和免疫沉淀实验，发现TOB1在乳腺癌细胞中通过与ERK1/2相互作用抑制其磷酸化，从而抑制肿瘤细胞增殖。研究提示TOB1可能作为乳腺癌治疗的潜在靶点。
2. **文献名称**: "TOB1在T细胞活化中的功能研究"
**作者**: Smith J, et al.
**摘要**: 通过TOB1抗体(Ab-164)的免疫荧光染色，研究者发现TOB1在T细胞受体激活后易位至细胞核，调控IL-2等细胞因子的表达。实验表明TOB1缺失会导致T细胞过度活化，证实其在免疫调节中的关键作用。
3. **文献名称**: "结直肠癌组织中TOB1蛋白表达与预后的相关性"
**作者**: Wang H, et al.
**摘要**: 利用TOB1抗体(Ab-164)对200例结直肠癌样本进行免疫组化分析，发现TOB1低表达与患者总生存期缩短显著相关。研究支持TOB1作为结直肠癌预后生物标志物的潜力。
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**备注**：以上文献为示例性质，实际研究中请通过学术数据库(如PubMed、Google Scholar)以关键词“TOB1 antibody Ab-164”或“TOB1 Ab-164 application”检索具体文献，并确认抗体的货号、物种来源及实验应用场景。
The TOB1 (Ab-164) antibody is a monoclonal antibody specifically designed to detect the TOB1 protein, a member of the Transducer of ERBB2 (TOB) family. TOB1. encoded by the TOB1 gene, functions as a tumor suppressor and regulates cell cycle progression, apoptosis, and cellular differentiation. It interacts with components of the ERK signaling pathway and modulates transcriptional activity by binding to transcription factors like SMAD or cyclin-dependent kinase inhibitors. TOB1 is ubiquitously expressed, with roles in immune regulation, neuronal development, and cancer biology. Dysregulation of TOB1 has been implicated in malignancies such as breast, lung, and gastric cancers, where its downregulation correlates with poor prognosis.
The Ab-164 clone recognizes an epitope within the C-terminal region of human TOB1. enabling specific detection of endogenous TOB1 in applications like Western blotting, immunoprecipitation, and immunohistochemistry. Its validation in multiple experimental models supports its utility in studying TOB1’s molecular interactions and functional mechanisms. Researchers employ this antibody to explore TOB1’s involvement in tumor suppression pathways, its crosstalk with oncogenic signaling, and its potential as a therapeutic biomarker. The antibody’s reliability in distinguishing TOB1 from homologous family members (e.g., TOB2) enhances its value in both basic research and translational studies.
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