| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (Membrane component chromosome X surface marker 1) (T-cell acute lymphoblastic leukemia-associated antigen 1) (TALLA-1) (Transmembrane 4 superfamily member 2) (CD antigen CD231) |
| Entrez GeneID | 7102; |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide from human protein at AA range: 101-150 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于Vitamin D3 Receptor (Ab-51)抗体的参考文献及其摘要概括：
1. **"Vitamin D receptor in colorectal cancer is associated with survival"**
- **作者**: Kornek, T. et al.
- **摘要**: 研究通过免疫组化(使用Ab-51抗体)发现结肠癌组织中维生素D受体(VDR)高表达与患者生存率改善相关，提示VDR可能作为预后标志物。
2. **"Vitamin D receptor expression in breast cancer tissue and its association with tumor progression"**
- **作者**: Brenner, H. et al.
- **摘要**: 利用Western blot和免疫荧光(Ab-51抗体)分析乳腺癌组织中VDR的表达水平，发现低表达与肿瘤侵袭性增强相关，提示VDR的抑癌作用。
3. **"The role of vitamin D receptor in bone metabolism regulation"**
- **作者**: Fleet, J.C. et al.
- **摘要**: 通过ChIP-seq和基因敲除技术(结合Ab-51抗体)，阐明VDR在成骨细胞分化中的调控机制，揭示其通过结合特定DNA序列激活骨代谢相关基因。
4. **"Autoimmune thyroid disease and vitamin D receptor polymorphism"**
- **作者**: Wang, L. et al.
- **摘要**: 采用ELISA和免疫沉淀(Ab-51抗体)检测VDR蛋白水平，发现特定VDR基因多态性与自身免疫性甲状腺疾病易感性相关。
注：以上文献为示例性内容，实际引用需根据具体研究核实。若需精确文献，建议通过PubMed或抗体供应商(如CST、Abcam)的产品引用列表查询。
The Vitamin D3 Receptor (VDR) is a nuclear hormone receptor that mediates the genomic effects of 1.25-dihydroxyvitamin D3. the biologically active form of vitamin D. VDR regulates gene expression involved in calcium-phosphate homeostasis, cell proliferation, differentiation, immune function, and metabolic processes. Upon ligand binding, VDR forms a heterodimer with the retinoid X receptor (RXR) and binds to vitamin D response elements (VDREs) in target gene promoters, modulating transcription. Dysregulation of VDR signaling is linked to osteoporosis, autoimmune diseases, cancer, and metabolic disorders.
The VDR (Ab-51) antibody is a specific monoclonal or polyclonal antibody designed to detect VDR, often targeting a defined epitope or post-translational modification (e.g., phosphorylation at a specific residue, such as Ser-51). It is widely used in research applications like Western blotting, immunohistochemistry, and immunofluorescence to study VDR expression, localization, and activation in various tissues and disease models. This antibody is particularly valuable for investigating VDR’s role in cellular responses to vitamin D, its interplay with signaling pathways, and its therapeutic implications. By enabling precise detection of VDR isoforms or modified forms, Ab-51 aids in elucidating mechanisms underlying vitamin D’s pleiotropic effects and its potential in treating VDR-associated pathologies. Its specificity and reliability make it a critical tool for advancing molecular and clinical research on vitamin D biology.
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