| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Early response protein NAK1; GFRP; GFRP1; HMR; N10 |
| Entrez GeneID | 3164; |
| WB Predicted band size | 60kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human Nuclear Receptor NR4A1 around the phosphorylation site of serine 351 (L-P-S(p)-K-P). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Nuclear Receptor NR4A1 (Ab-351)抗体的3篇参考文献示例(注：文献信息为模拟生成，实际引用需核实)：
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1. **Title**: *NR4A1 regulates macrophage polarization in atherosclerosis*
**Author**: Li, X. et al.
**Summary**: 本研究利用NR4A1 (Ab-351)抗体，通过免疫组化和Western blot分析，揭示NR4A1在动脉粥样硬化中调控巨噬细胞从促炎M1型向抗炎M2型极化的机制，表明NR4A1缺失加剧斑块炎症。
2. **Title**: *NR4A1-dependent apoptosis in T-cell acute lymphoblastic leukemia*
**Author**: Smith, J. & Wang, Y.
**Summary**: 通过NR4A1 (Ab-351)抗体的ChIP-seq和流式细胞术，研究发现NR4A1通过激活促凋亡基因Bim表达，诱导T细胞白血病凋亡，提示其作为治疗靶点的潜力。
3. **Title**: *NR4A1 modulates hepatic glucose metabolism via PGC-1α interaction*
**Author**: Garcia, R. et al.
**Summary**: 该研究使用NR4A1 (Ab-351)抗体进行共免疫沉淀实验，证明NR4A1与PGC-1α互作调控肝脏糖异生，敲除小鼠模型显示NR4A1缺失导致空腹血糖异常升高。
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**注意**：以上文献为示例，实际研究中请通过PubMed或Google Scholar以关键词“NR4A1 Ab-351 antibody”或抗体货号(如Abcam ab351)检索，并核实抗体使用描述及研究相关性。
The nuclear receptor NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1), also known as Nur77. TR3. or NGFIB, is a ligand-independent transcription factor belonging to the NR4A subfamily. It plays critical roles in cellular processes such as proliferation, apoptosis, inflammation, and metabolism. NR4A1 is involved in immune regulation, vascular homeostasis, and cancer progression, acting as both an oncogene and tumor suppressor depending on cellular context. It localizes to the nucleus under basal conditions but translocates to mitochondria during stress-induced apoptosis, interacting with Bcl-2 proteins to trigger cytochrome c release.
The NR4A1 (Ab-351) antibody is a specific monoclonal or polyclonal reagent designed to detect endogenous levels of NR4A1 protein in applications like Western blotting, immunohistochemistry, and immunofluorescence. The "Ab-351" designation typically refers to an antibody targeting a defined phosphorylation site (e.g., Ser351) or a specific epitope within the NR4A1 protein, enabling researchers to study post-translational modifications or functional states. Validated for species cross-reactivity (often human, mouse, rat), this antibody aids in investigating NR4A1's role in diseases like cancer, atherosclerosis, and autoimmune disorders. Proper validation using knockout controls is essential due to potential cross-reactivity with related NR4A family members (NR4A2/NURR1. NR4A3/NOR1).
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