Rabbit Polyclonal hnRPD(Ab-83) Antibody

The hnRNP D (Ab-83) antibody is a widely used tool in molecular biology research, targeting the heterogeneous nuclear ribonucleoprotein D (hnRNP D), also known as AU-rich element RNA-binding protein 1 (AUF1). hnRNP D is a member of the hnRNP family, involved in post-transcriptional gene regulation, including mRNA stability, splicing, and translation. It binds to AU-rich elements (AREs) in the 3' untranslated regions of mRNAs, particularly those encoding cytokines, proto-oncogenes, and stress-response proteins, facilitating their degradation or stabilization under varying cellular conditions. The Ab-83 clone, often raised in mice, recognizes specific isoforms (e.g., p37. p40. p42. p45) of hnRNP D, enabling researchers to study its role in processes like inflammation, cancer progression, and cellular stress responses. This antibody is validated for applications such as Western blotting, immunoprecipitation, and immunofluorescence. Its utility extends to investigating diseases linked to dysregulated RNA metabolism, such as neurodegeneration and malignancies, where hnRNP D expression or function may be altered. The antibody's specificity and reliability make it a key reagent for dissecting RNA-protein interactions and their implications in health and disease.