Rabbit Polyclonal Syndecan4(Ab-179) Antibody

The Syndecan4 (Ab-179) antibody is a monoclonal antibody specifically designed to recognize human Syndecan-4 (SDC4), a transmembrane heparan sulfate proteoglycan belonging to the syndecan family. Syndecan-4 plays critical roles in cell adhesion, migration, and signaling by interacting with extracellular matrix components, growth factors (e.g., FGF, VEGF), and cytoskeletal proteins. It is unique among syndecans due to its ability to regulate protein kinase Cα (PKCα) and small GTPases, influencing processes like wound healing, angiogenesis, and tissue repair. The Ab-179 antibody typically targets an epitope near the C-terminal cytoplasmic domain of SDC4. often used to study its phosphorylation at Ser179. a modification linked to cytoskeletal reorganization and cellular responses to mechanical stress. Researchers employ this antibody in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate SDC4 expression, localization, and function in diseases like cancer, fibrosis, and cardiovascular disorders. Its specificity makes it a valuable tool for exploring SDC4's dual role as a co-receptor in growth factor signaling and a mediator of cell-matrix interactions, particularly in contexts involving tissue remodeling or pathological inflammation.