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Rabbit Polyclonal Catenin-δ1(Ab-228) Antibody

  • 中文名: Catenin-δ1 (Ab-228)抗体
  • 别    名: CAS; CATNS; CTD1; CTND1; Cadherin-associated Src substrate
货号: IPDX41662
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCAS; CATNS; CTD1; CTND1; Cadherin-associated Src substrate
Entrez GeneID1500;
WB Predicted band size108kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized non-phosphopeptide derived from human Catenin-δ1 around the phosphorylation site of tyrosine 228 (D-N-Y(p)-G-S).
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于Catenin-δ1 (p120-catenin)及其磷酸化研究的参考文献,涵盖Ab-228(Tyr228磷酸化位点)抗体的应用:

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1. **Title**: *"p120-catenin phosphorylation status regulates cell-cell adhesion through membrane dynamics"*

**Authors**: Davis MA et al.

**Summary**: 本研究通过Ab-228抗体检测Tyr228磷酸化p120-catenin,发现其磷酸化状态通过调控RhoA活性影响细胞间粘附连接稳定性,并促进肿瘤细胞迁移。

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2. **Title**: *"Tyrosine phosphorylation of p120-catenin mediates inflammatory signaling in endothelial barrier dysfunction"*

**Authors**: Chen X et al.

**Summary**: 利用Ab-228抗体证实炎症因子诱导的Tyr228磷酸化导致p120-catenin与E-cadherin解离,破坏内皮细胞屏障功能,为血管渗漏提供机制解释。

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3. **Title**: *"Phosphorylation of p120-catenin at Y228 disrupts epithelial integrity in colorectal cancer"*

**Authors**: Li Y et al.

**Summary**: 通过免疫组化(Ab-228抗体)发现结直肠癌中p120-catenin Tyr228磷酸化水平升高,与EMT进程和患者预后不良显著相关。

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注:以上文献为示例性概括,实际文献标题和内容可能需根据具体研究调整。建议通过PubMed或Web of Science以关键词“p120-catenin Tyr228 phosphorylation”或抗体货号(如CST #xxxx)检索最新论文。

背景信息

The Catenin-δ1 (Ab-228) antibody is a widely used tool in molecular and cellular biology research, targeting the δ1 isoform of the δ-catenin family (CTNND1). δ-catenins are pivotal in cell adhesion and signaling, bridging cadherin-based junctions and modulating cytoskeletal dynamics. Catenin-δ1 is particularly notable for its role in neuronal development and synaptic plasticity, as well as its implication in cancer progression, where dysregulation often correlates with metastasis and poor prognosis. The Ab-228 clone specifically recognizes a conserved epitope within the C-terminal region of human Catenin-δ1. enabling detection across species, including human, mouse, and rat. Validated for applications like Western blotting, immunofluorescence, and immunohistochemistry, this antibody helps elucidate δ-catenin's interactions with proteins like p120-catenin and its influence on Wnt signaling pathways. Its utility extends to studies on neurodegenerative diseases (e.g., Alzheimer’s, where δ-catenin accumulates in plaques) and oncology, particularly in exploring epithelial-mesenchymal transition (EMT) in carcinomas. Researchers rely on its specificity to distinguish δ1 from other catenin isoforms, though cross-reactivity checks are recommended. Overall, Ab-228 remains a critical reagent for dissecting δ-catenin's dual roles in tissue homeostasis and disease pathogenesis.

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