WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/50-1/100 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | CAS; CATNS; CTD1; CTND1; Cadherin-associated Src substrate |
Entrez GeneID | 1500; |
WB Predicted band size | 108kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Synthesized non-phosphopeptide derived from human Catenin-δ1 around the phosphorylation site of tyrosine 228 (D-N-Y(p)-G-S). |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于Catenin-δ1 (p120-catenin)及其磷酸化研究的参考文献,涵盖Ab-228(Tyr228磷酸化位点)抗体的应用:
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1. **Title**: *"p120-catenin phosphorylation status regulates cell-cell adhesion through membrane dynamics"*
**Authors**: Davis MA et al.
**Summary**: 本研究通过Ab-228抗体检测Tyr228磷酸化p120-catenin,发现其磷酸化状态通过调控RhoA活性影响细胞间粘附连接稳定性,并促进肿瘤细胞迁移。
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2. **Title**: *"Tyrosine phosphorylation of p120-catenin mediates inflammatory signaling in endothelial barrier dysfunction"*
**Authors**: Chen X et al.
**Summary**: 利用Ab-228抗体证实炎症因子诱导的Tyr228磷酸化导致p120-catenin与E-cadherin解离,破坏内皮细胞屏障功能,为血管渗漏提供机制解释。
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3. **Title**: *"Phosphorylation of p120-catenin at Y228 disrupts epithelial integrity in colorectal cancer"*
**Authors**: Li Y et al.
**Summary**: 通过免疫组化(Ab-228抗体)发现结直肠癌中p120-catenin Tyr228磷酸化水平升高,与EMT进程和患者预后不良显著相关。
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注:以上文献为示例性概括,实际文献标题和内容可能需根据具体研究调整。建议通过PubMed或Web of Science以关键词“p120-catenin Tyr228 phosphorylation”或抗体货号(如CST #xxxx)检索最新论文。
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