Rabbit Polyclonal p9RSK(Ab-573) Antibody

The p90 ribosomal S6 kinase (p90RSK), a downstream effector of the ERK/MAPK signaling pathway, plays a critical role in regulating cell proliferation, survival, and differentiation. Phosphorylation at specific residues, such as Thr573 (p9RSK, often referenced as Ab-573 in antibody catalogues), is essential for its activation. This phosphorylation event, mediated by ERK1/2. triggers a conformational change that enables p90RSK to phosphorylate substrates involved in transcription, translation, and apoptosis. Antibodies targeting phosphorylated p90RSK (e.g., Ab-573) are widely used to study its activation status in cellular responses to growth factors, stress, or pharmacological inhibitors. These antibodies are particularly valuable in cancer research, as aberrant RSK activation is linked to tumor progression and therapy resistance. They are also applied in neuroscience to explore RSK's role in synaptic plasticity and neurodegenerative diseases. Validation of such antibodies typically includes Western blotting, immunofluorescence, and immunohistochemistry to ensure specificity for the phosphorylated epitope. Researchers rely on p9RSK (Ab-573) antibodies to dissect signaling dynamics in disease models, drug screening, and mechanistic studies, making them essential tools for understanding RSK-mediated regulatory networks.