Rabbit Polyclonal EPOR Antibody

The erythropoietin receptor (EPOR) is a transmembrane protein belonging to the cytokine receptor superfamily, primarily expressed on erythroid progenitor cells. It mediates erythropoietin (EPO)-stimulated signaling through JAK-STAT pathways, promoting red blood cell production. EPOR antibodies are tools designed to detect, quantify, or modulate this receptor in research and clinical contexts. In research, they are used to study EPOR expression patterns, signaling mechanisms, and interactions in conditions like anemia, myeloproliferative disorders, and cancers where EPOR may be aberrantly expressed. Clinically, anti-EPOR antibodies have therapeutic potential; for example, blocking antibodies could inhibit EPOR hyperactivity in polycythemia vera, while agonist antibodies might mimic EPO in anemia treatment. Commercially available EPOR antibodies vary in specificity (monoclonal vs. polyclonal) and applications (Western blot, immunohistochemistry, flow cytometry). Challenges include ensuring antibody specificity due to EPOR isoforms and post-translational modifications. Some studies also explore EPOR's non-erythropoietic roles in neuroprotection or tumor progression, expanding the utility of these antibodies. Validation using knockout models or neutralizing controls is critical to avoid off-target effects, particularly in complex biological samples.