| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Synpr |
| Entrez GeneID | 66030; |
| WB Predicted band size | 37kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.257~261(G-P-T-S-F)derived from Rat synaptophysin 2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **synaptophysin 2(SYN2)抗体** 的参考文献示例，包含文献名称、作者及摘要概述：
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1. **"Characterization of a novel synaptophysin 2 antibody for synaptic vesicle research"**
*Smith A, et al. (2018)*
摘要：研究团队开发了一种针对SYN2的高特异性单克隆抗体，通过Western blot和免疫组化验证其在大脑组织中的选择性标记，证实SYN2在突触前膜中的定位，并用于分析神经退行性疾病模型中的突触功能异常。
2. **"Synaptophysin 2 regulates synaptic plasticity via vesicle recycling in hippocampal neurons"**
*Lee J, et al. (2015)*
摘要：本文利用SYN2抗体研究其在海马神经元突触囊泡循环中的作用，发现SYN2敲除小鼠出现突触传递缺陷，抗体通过免疫荧光和共聚焦显微镜揭示了SYN2与突触蛋白复合物的动态相互作用。
3. **"Altered expression of synaptophysin 2 in schizophrenia: An immunohistochemical study"**
*Chen X, et al. (2020)*
摘要：通过SYN2抗体对精神分裂症患者尸检脑组织进行免疫组化分析，发现前额叶皮层SYN2表达显著降低，提示其与突触连接异常和精神病理学的潜在关联。
4. **"Development and validation of a rabbit polyclonal antibody for synaptophysin 2 in cancer diagnostics"**
*Wang Y, et al. (2021)*
摘要：研究报道了一种兔源多克隆SYN2抗体的开发，验证其在肿瘤组织中的特异性染色能力，发现SYN2在神经内分泌肿瘤中高表达，可作为潜在诊断标志物。
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*注：上述文献为示例性质，实际引用时需核实真实存在的论文及细节。*
Synaptophysin 2 (SYN2) is a member of the synaptophysin family of transmembrane glycoproteins, primarily localized to synaptic vesicles in neurons. It shares structural homology with synaptophysin 1 (SYN1), including four transmembrane domains and a C-terminal tail, but exhibits distinct expression patterns and functional roles. SYN2 is implicated in synaptic vesicle trafficking, neurotransmitter release, and synaptic plasticity. Unlike SYN1. which is broadly expressed in presynaptic terminals, SYN2 shows more restricted expression, enriched in specific neuronal subtypes and brain regions, such as the hippocampus and cerebral cortex, suggesting specialized roles in neural circuit regulation.
Antibodies targeting SYN2 are critical tools for investigating its distribution, interaction partners, and involvement in neurological processes. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize SYN2 expression in brain tissues or cultured neurons. Researchers employ SYN2 antibodies to explore its contributions to synaptic dysfunction in neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) and neuropsychiatric disorders. Specificity validation via knockout controls or siRNA knockdown is essential, as cross-reactivity with other synaptophysin family members can occur. Recent studies also highlight SYN2's potential role in regulating calcium signaling and vesicle endocytosis, making its antibodies valuable for dissecting molecular mechanisms underlying synaptic transmission and pathology.
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