| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | POSTN; OSF2; OSF-2; PN; osteoblast specific factor |
| Entrez GeneID | 50706; |
| WB Predicted band size | 93kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa. 125~129( R-E-E-I-E) derived from Mouse Periostin. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Periostin抗体的3篇参考文献及其摘要概述：
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1. **文献名称**：*Targeting Periostin in Cardiac Fibrosis: Insights from a Genetic Knockout Model*
**作者**：Conway SJ, et al.
**摘要**：该研究通过构建Periostin基因敲除小鼠模型，结合特异性抗体检测，发现Periostin在心肌纤维化中显著上调。抗体阻断实验表明，抑制Periostin可减少胶原沉积并改善心脏功能，提示其作为抗纤维化治疗靶点的潜力。
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2. **文献名称**：*Development of a Novel Monoclonal Antibody Against Human Periostin for Asthma Biomarker Analysis*
**作者**：Izuhara K, et al.
**摘要**：研究团队开发了一种高特异性抗人Periostin单克隆抗体，用于定量哮喘患者血清及支气管肺泡灌洗液中的Periostin水平。结果显示，Periostin表达与气道重塑严重程度相关，为哮喘的个性化治疗提供了新生物标志物。
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3. **文献名称**：*Periostin Antibody Inhibits Tumor Metastasis by Disrupting Cancer-Stroma Interactions*
**作者**：Kudo Y, et al.
**摘要**：该研究利用兔源多克隆抗体，探究Periostin在肿瘤微环境中的作用。实验表明，抗体通过阻断Periostin与整合素受体的结合，抑制肿瘤细胞与间质细胞的相互作用，从而显著降低乳腺癌小鼠模型的肺转移率。
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**备注**：以上文献为示例性内容，实际引用时需核实具体来源及细节。如需更多信息，建议通过PubMed或Web of Science以“Periostin antibody”为关键词检索最新研究。
Periostin, encoded by the *POSTN* gene, is a secreted extracellular matrix (ECM) protein primarily known for its role in tissue repair, fibrosis, and cancer progression. It interacts with integrins and other ECM components, regulating cell adhesion, migration, and differentiation. Periostin is overexpressed in pathological conditions such as fibrosis, chronic inflammation, and tumors, serving as a biomarker for disease severity in asthma, idiopathic pulmonary fibrosis, and metastatic cancers.
Periostin antibodies are immunological tools designed to detect, quantify, or neutralize periostin in research and clinical settings. Polyclonal and monoclonal variants target specific epitopes, enabling applications in Western blotting, immunohistochemistry (IHC), and ELISA. For instance, clone PN1A3 is widely used in IHC to assess periostin expression in tissue samples, while neutralizing antibodies (e.g., clone mMAb 3671) inhibit periostin-integrin interactions in functional studies. Therapeutic anti-periostin antibodies are also under investigation to block pro-fibrotic or tumor-promoting pathways.
Despite their utility, challenges remain, including epitope specificity across species and isoforms. Recent studies highlight periostin’s dual roles in tissue regeneration versus pathological remodeling, necessitating context-dependent antibody applications. Ongoing research aims to refine antibody targeting for precision diagnostics and therapies.
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