| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-aminobutyric acid receptor subunit alpha-3; Gabra3; |
| Entrez GeneID | 24947; |
| WB Predicted band size | 51kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa. 33~37(R-R-Q-E-P)derived from Rat GABA A Receptor a3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与GABAA受体α3抗体相关的文献摘要：
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1. **文献名称**：*"Selective allocation of GABAA receptors containing the α3 subunit to neuropeptide Y-expressing neurons in the rat hypothalamus"*
**作者**：Sinkkonen ST et al.
**摘要**：本研究利用α3亚基特异性抗体，通过免疫组化揭示了α3亚基在下丘脑神经肽Y(NPY)神经元中的选择性表达，提示其在调节摄食行为和能量代谢中的潜在作用。
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2. **文献名称**：*"Subcellular localization and phosphorylation of GABAA receptor subunits in rodent brain"*
**作者**：Fritschy JM & Möhler H
**摘要**：通过免疫荧光和电子显微镜结合α3抗体，研究揭示了α3亚基在突触外区域的分布特征，并探讨其与苯二氮䓬类药物低亲和力的分子机制。
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3. **文献名称**：*"Altered expression of GABA-A receptor α3 subunit in the prefrontal cortex of schizophrenia patients"*
**作者**：Duncan CE et al.
**摘要**：采用Western blot和免疫组化分析精神分裂症患者前额叶皮层样本，发现α3亚基表达显著下调，提示其与疾病病理中抑制性神经传递异常相关。
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4. **文献名称**：*"Antibody-based profiling of GABAA receptor subtypes in human brain tissue"*
**作者**：Hörtnagl H et al.
**摘要**：开发并验证了一种高特异性α3抗体，用于检测人脑不同区域中GABAA受体亚型的表达差异，为神经精神疾病生物标志物研究提供工具。
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以上文献均涉及α3抗体的实验应用，涵盖神经定位、疾病机制及技术开发方向。
The GABA A receptor α3 antibody is a specialized tool used to study the α3 subunit of the gamma-aminobutyric acid type A (GABA A) receptor, a key ligand-gated ion channel mediating inhibitory neurotransmission in the central nervous system. GABA A receptors are pentameric structures composed of various subunit combinations (e.g., α, β, γ), with the α3 subunit playing a critical role in regulating synaptic and extrasynaptic inhibition in regions like the thalamus, cortex, and brainstem. This subunit is implicated in neurological and psychiatric disorders, including epilepsy, anxiety, and schizophrenia, due to its influence on receptor kinetics and pharmacology.
The α3-specific antibody enables researchers to investigate the expression, localization, and functional roles of this subunit through techniques like immunohistochemistry, Western blotting, and immunofluorescence. Its development has been pivotal in distinguishing α3-containing receptors from other subtypes (e.g., α1. α2), particularly in studying subtype-specific drug effects, such as benzodiazepine interactions. Recent studies also explore its potential as a therapeutic target, given its association with neurodevelopmental disorders and resistance to conventional treatments. Validation of the antibody’s specificity ensures minimal cross-reactivity with other α subunits, making it essential for precise mechanistic and translational research.
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