| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SSXT; MGC116875; |
| Entrez GeneID | 6760; |
| WB Predicted band size | 60kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.14~18(G-E-I-T-P) derived from Human SYT. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SYT(Synaptotagmin)抗体的3篇参考文献的简要信息：
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1. **文献名称**：*Autoantibodies to synaptotagmin in a patient with cerebellar ataxia and terminal cancer*
**作者**：Graus F, et al.
**摘要内容**：该研究报道了一例小脑共济失调合并晚期癌症患者的病例，发现其血清中存在针对突触结合蛋白(SYT)的自身抗体。研究提示SYT抗体可能与副肿瘤性神经系统综合征相关，并可能通过干扰突触传递导致神经功能障碍。
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2. **文献名称**：*Detection of SYT-SSX fusion transcripts in synovial sarcoma using reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization*
**作者**：Kawai A, et al.
**摘要内容**：研究开发了一种基于RT-PCR和荧光原位杂交(FISH)的方法，用于检测滑膜肉瘤中SYT-SSX融合基因的表达。SYT抗体在此类肿瘤的免疫组化诊断中具有辅助价值，有助于区分其他软组织肿瘤。
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3. **文献名称**：*Synaptotagmin I is a molecular target for mercury-induced inhibition of exocytosis*
**作者**：Pendergrass JC, et al.
**摘要内容**：通过使用SYT特异性抗体，研究发现汞(Hg²⁺)通过结合突触结合蛋白I(SYT1)抑制神经递质的释放，揭示了SYT在突触囊泡融合中的关键作用及其在重金属神经毒性中的机制。
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**备注**：SYT抗体在研究中通常分为两类：一类是用于检测疾病相关自身抗体的诊断工具(如副肿瘤综合征)，另一类是作为实验工具研究SYT蛋白的生理功能(如突触传递)。上述文献涵盖了临床和基础研究的不同方向。
Synaptotagmin (SYT) antibodies are primarily associated with the detection and study of synaptotagmin proteins, a family of calcium-sensitive transmembrane proteins involved in synaptic vesicle trafficking and neurotransmitter release. The SYT family comprises 17 isoforms in humans, with SYT-1 being the most extensively studied due to its critical role in fast calcium-triggered exocytosis in neurons and neuroendocrine cells. SYT antibodies are widely utilized in neuroscience research to investigate synaptic function, neurodegenerative disorders (e.g., Alzheimer's and Parkinson's diseases), and psychiatric conditions.
In clinical contexts, SYT antibodies gained prominence in cancer diagnostics, particularly for synovial sarcoma (SS), where the SYT-SSX fusion gene (resulting from t(X;18) translocation) serves as a molecular hallmark. Antibodies targeting the C-terminal region of SYT help identify this fusion protein in immunohistochemical assays, aiding SS diagnosis and differentiation from histologically similar tumors.
Additionally, SYT antibodies have been implicated in autoimmune research. Anti-SYT1 antibodies are occasionally detected in paraneoplastic neurological syndromes, though their pathogenicity remains unclear. Recent studies also explore SYT isoforms (e.g., SYT-IX) in non-neuronal tissues, suggesting roles in membrane repair and cancer progression. Commercial SYT antibodies vary in specificity across isoforms, necessitating rigorous validation for experimental accuracy. Ongoing research continues to refine their applications in both basic science and clinical diagnostics.
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