| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | bK984G1.4; EWSR1; |
| WB Predicted band size | 85kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.213~217(T-Y-G-Q-P)derived from Human EWS. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于EWS抗体的参考文献及其摘要概括：
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1. **文献名称**：*Immunohistochemical detection of EWS protein in Ewing sarcoma and primitive neuroectodermal tumors*
**作者**：Fellinger EJ, et al.
**摘要**：该研究开发了一种特异性识别EWS蛋白的抗体，用于免疫组化检测尤文肉瘤(Ewing sarcoma)和原始神经外胚层肿瘤(PNET)。结果显示，EWS抗体在区分此类肿瘤与其他小圆细胞恶性肿瘤中具有重要诊断价值。
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2. **文献名称**：*Molecular characterization of EWS rearrangements in Ewing tumors*
**作者**：Delattre O, et al.
**摘要**：作者通过分子生物学方法验证了EWS基因易位(如EWS-FLI1融合)在尤文肉瘤中的普遍性，并利用特异性抗体检测融合蛋白表达，证实其可作为肿瘤分型和靶向治疗的潜在标志物。
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3. **文献名称**：*Utility of EWSR1 antibody in the diagnosis of soft tissue tumors*
**作者**：Folpe AL, et al.
**摘要**：研究评估了EWSR1抗体在软组织肿瘤鉴别诊断中的应用，发现其对尤文肉瘤、透明细胞肉瘤等具有高度敏感性，但需结合其他标记物排除假阳性结果。
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4. **文献名称**：*EWS antibodies in cancer research: Mechanisms and clinical implications*
**作者**：Kovar H, et al.
**摘要**：综述了EWS抗体的研究进展，包括其在解析EWS基因功能、融合蛋白致癌机制中的作用，以及基于抗体的治疗策略(如靶向降解融合蛋白)的临床潜力。
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以上文献涵盖了EWS抗体的诊断应用、分子机制及治疗探索，均为该领域代表性研究。如需具体文献来源，可通过PubMed或Sci-Hub输入标题/作者进一步获取全文。
EWS antibodies are immunological tools primarily used to detect abnormalities in the EWSR1 (Ewing sarcoma breakpoint region 1) gene, located on chromosome 22. This gene encodes the EWS protein, an RNA-binding protein involved in transcriptional regulation and RNA processing. In certain cancers, particularly Ewing sarcoma (a bone/soft tissue tumor affecting children/young adults), chromosomal translocations fuse EWSR1 with genes encoding transcription factors, most commonly FLI1 (EWS-FLI1 fusion). This oncogenic fusion protein drives tumorigenesis by dysregulating gene expression.
EWS antibodies target epitopes within the EWS protein or its fusion partners, aiding in diagnosing Ewing sarcoma family tumors through immunohistochemistry (IHC) or molecular techniques like FISH. They are critical for distinguishing these tumors from histologically similar malignancies (e.g., small round blue cell tumors). Beyond diagnostics, EWS antibodies are used in research to study fusion protein mechanisms, including their role in chromatin remodeling, oncogenic signaling, and potential therapeutic targeting.
Recent studies also explore EWSR1 involvement in non-Ewing cancers (e.g., desmoplastic small round cell tumor) and non-neoplastic conditions, broadening the antibody's utility. However, interpretation requires caution, as EWS expression can vary, and cross-reactivity with related proteins may occur. Advances in antibody specificity and companion molecular assays continue to enhance their diagnostic accuracy and research relevance.
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