| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FAM129A |
| Entrez GeneID | 116496; |
| WB Predicted band size | 150kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | peptide sequence around aa. 912~916 (K-E-G-E-G) derived from Human Niban. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Niban抗体的3篇参考文献(注：因文献检索条件限制，以下内容为模拟示例，实际文献需通过学术数据库确认)：
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1. **文献名称**: *Niban regulates endoplasmic reticulum stress and apoptosis in renal cancer cells*
**作者**: Tanaka N, et al.
**摘要**: 本研究利用Niban特异性抗体探讨了Niban蛋白在肾癌细胞中对内质网应激反应的调控机制，发现其通过抑制CHOP通路减少细胞凋亡，提示其在肾癌进展中的潜在作用。
2. **文献名称**: *Development of a monoclonal antibody against human Niban protein for immunohistochemical analysis*
**作者**: Sato Y, et al.
**摘要**: 研究团队开发了一种高特异性抗人Niban单克隆抗体，并验证了其在结直肠癌组织免疫组化染色中的应用，证实Niban在癌旁组织中的高表达与患者预后相关。
3. **文献名称**: *FAM129A (Niban) promotes melanoma invasion by modulating EGFR signaling*
**作者**: Chen L, et al.
**摘要**: 通过Western blot和免疫荧光(使用Niban抗体)，研究发现FAM129A/Niban通过激活EGFR信号通路增强黑色素瘤细胞的侵袭能力，为靶向治疗提供了新方向。
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建议通过PubMed或Google Scholar以“Niban antibody”、“FAM129A antibody”等关键词检索真实文献。
**Background of Niban Antibody**
The Niban antibody targets the Niban protein, also known as FAM129A, a stress-responsive protein implicated in cellular survival mechanisms under adverse conditions. Initially identified in 2005. Niban gained attention due to its overexpression in renal and colorectal cancers, suggesting a potential role in tumorigenesis. It is regulated by p53 and ATF4. linking it to pathways involved in endoplasmic reticulum (ER) stress, unfolded protein response (UPR), and apoptosis evasion.
Structurally, Niban contains an N-terminal domain critical for its anti-apoptotic function and a C-terminal region with proline-rich motifs that may mediate protein interactions. Studies highlight its involvement in mTOR and NF-κB signaling, promoting cell survival under stress. Elevated Niban expression correlates with poor prognosis in cancers, positioning it as a biomarker and therapeutic target.
Research tools like Niban antibodies enable detection of its expression in tissues or cell lines, aiding mechanistic studies. Recent investigations explore its role beyond cancer, including metabolic diseases and neurodegeneration, where ER stress pathways are dysregulated. Despite progress, the precise molecular mechanisms of Niban remain under investigation, with ongoing efforts to develop inhibitors targeting its oncogenic functions.
In summary, Niban antibodies serve as vital reagents for unraveling the protein's role in stress adaptation and disease, offering translational potential in diagnostics and therapy.
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