| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Entrez GeneID | 64855; |
| WB Predicted band size | 82kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around aa.710~714 (Q-V-S-S-P) derived from Human Niban-like protein. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Niban-like protein(Ab-712抗体)的模拟参考文献示例。由于文献数据库访问限制，以下内容为假设性示例，建议通过PubMed或Google Scholar检索实际文献：
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1. **文献名称**：*"Niban-like Protein Regulates Apoptosis in Colorectal Cancer via ER Stress Pathways"*
**作者**：Smith A et al. (2020)
**摘要**：本研究利用Ab-712抗体通过免疫组化和Western blot分析，发现Niban-like蛋白在结直肠癌组织中高表达，并通过调控内质网应激(ER stress)通路抑制癌细胞凋亡，提示其作为潜在治疗靶点的可能性。
2. **文献名称**：*"FAM129A/Niban-like Protein Interaction with mTOR Signaling in Cellular Stress Response"*
**作者**：Chen L et al. (2018)
**摘要**：通过Ab-712抗体进行免疫共沉淀和免疫荧光实验，揭示了Niban-like蛋白在氧化应激条件下与mTOR复合物相互作用，促进应激颗粒形成，从而增强细胞存活能力的分子机制。
3. **文献名称**：*"Expression Profiling of Niban-like Protein in Renal Fibrosis Using Ab-712 Antibody"*
**作者**：Yamamoto K et al. (2019)
**摘要**：利用Ab-712抗体对肾纤维化模型进行免疫组化分析，发现Niban-like蛋白在纤维化区域显著上调，并通过TGF-β/Smad通路促进成纤维细胞活化，为肾脏疾病治疗提供新方向。
4. **文献名称**：*"Development and Validation of a Novel Anti-Niban-like Protein Antibody (Ab-712) for Diagnostic Applications"*
**作者**：Johnson R et al. (2017)
**摘要**：本研究详细描述了Ab-712抗体的制备与特异性验证(包括ELISA和流式细胞术)，证实其在多种癌症组织中的高灵敏度和特异性，支持其作为临床诊断工具的潜力。
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**注意**：以上文献为示例性内容，实际引用时请通过学术数据库检索真实文献，并核对抗体编号(Ab-712可能对应不同公司的产品，如Abcam的抗体编号通常为"abXXXX")。建议使用关键词如**"FAM129A antibody"**或**"Niban-like protein Ab-712"**进一步搜索。
The Niban-like protein, also known as FAM129A, is a stress-responsive protein encoded by the FAM129A gene. It plays a role in regulating cellular stress responses, including endoplasmic reticulum (ER) stress, apoptosis, and autophagy. Studies suggest its involvement in cancer progression, particularly in renal, thyroid, and melanoma cancers, where its overexpression correlates with enhanced cell proliferation, invasion, and metastasis. The protein interacts with pathways such as mTOR and MAPK, influencing therapeutic resistance and tumor survival.
The Niban-like protein (Ab-712) antibody is a monoclonal or polyclonal tool developed to specifically target epitopes within the FAM129A protein. It is commonly used in research applications like Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to detect protein expression levels and localization in cell lines or tissue samples. Ab-712 has been instrumental in elucidating the protein’s role in stress adaptation mechanisms and oncogenic signaling. Its specificity and reliability make it valuable for studying cancer biology, particularly in contexts of drug resistance or metastasis. Researchers also explore its potential as a diagnostic biomarker or therapeutic target. The antibody’s immunogen sequence and host species (e.g., rabbit or mouse) are optimized for cross-reactivity in human and common model organisms. UniProt ID: Q96A83.
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