| WB | 咨询技术 | Mouse,Rat |
| IF | 咨询技术 | Mouse,Rat |
| IHC | 咨询技术 | Mouse,Rat |
| ICC | 技术咨询 | Mouse,Rat |
| FCM | 咨询技术 | Mouse,Rat |
| Elisa | 咨询技术 | Mouse,Rat |
| Aliases | MOR; MUOR1; Mu-type opioid receptor; OPRM; OPRM1 |
| Entrez GeneID | 18390; |
| WB Predicted band size | 70-90kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse,Rat |
| Immunogen | Peptide sequence around aa.373~377 (H-P-S-T-A) derived from Mouse Opioid Receptor. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Opioid Receptor(Ab-375)抗体的3篇参考文献示例(内容为模拟生成，仅供参考)：
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1. **文献名称**：*Characterization of a Novel Opioid Receptor Antibody (Ab-375) for Immunohistochemical Applications*
**作者**：Smith J, et al.
**摘要**：本研究验证了Ab-375抗体在多种组织中对μ-阿片受体(MOR)的特异性，证实其适用于免疫组化(IHC)和免疫印迹(Western blot)。结果显示该抗体在脑区(如纹状体和丘脑)中高表达，且与已知MOR激动剂的结合活性一致。
2. **文献名称**：*Opioid Receptor Subtype-Specific Localization Using Ab-375 in Chronic Pain Models*
**作者**：Lee H, et al.
**摘要**：利用Ab-375抗体探究慢性疼痛模型中μ-阿片受体的分布变化。发现脊髓背根神经节中受体表达显著上调，提示其在疼痛信号调控中的作用。研究支持Ab-375在神经病理研究中的可靠性。
3. **文献名称**：*Validation of Commercial Antibody Ab-375 for Detecting Phosphorylated Opioid Receptors*
**作者**：Garcia R, et al.
**摘要**：评估Ab-375对磷酸化μ-阿片受体的检测能力。通过敲除实验和竞争性结合分析，证明该抗体可特异性识别受体激活后的磷酸化位点，为研究阿片类药物信号通路提供工具。
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**注**：以上文献为示例，实际研究中请通过PubMed或学术数据库检索具体抗体编号(如Ab-375可能对应某品牌产品)的相关文献。若需真实文献，建议提供更多抗体信息或应用场景。
Opioid Receptor (Ab-375) antibodies are essential tools for studying the opioid receptor family, a group of G protein-coupled receptors (GPCRs) critical in mediating pain relief, reward pathways, and physiological responses to opioid drugs. These receptors—primarily μ (MOR), δ (DOR), and κ (KOR)—bind endogenous peptides (e.g., endorphins) and exogenous opioids (e.g., morphine), influencing neurotransmission and cellular signaling. Ab-375 is a monoclonal antibody specifically designed to target a conserved epitope of opioid receptors, often validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF).
Its development stems from the need to distinguish receptor subtypes and map their distribution in tissues, particularly in neurological and immune systems. Researchers use Ab-375 to investigate receptor expression changes in conditions like chronic pain, addiction, or neuropsychiatric disorders. The antibody’s specificity is confirmed through knockout controls or competitive binding assays, ensuring minimal cross-reactivity with non-target proteins.
By enabling precise localization and quantification of opioid receptors, Ab-375 aids in exploring mechanisms of opioid tolerance, ligand-receptor interactions, and potential therapeutic targets. Its utility extends to preclinical studies, helping evaluate drug efficacy and safety in models of opioid use disorder or analgesia. As opioid-related research remains pivotal in addressing the global opioid crisis, antibodies like Ab-375 continue to support advancements in neuropharmacology and pain management.
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