Rabbit Polyclonal PKCth(Ab-676) Antibody

The PKCθ (Ab-676) antibody is a tool used to study protein kinase C theta (PKCθ), a member of the novel PKC subfamily predominantly expressed in T cells and skeletal muscle. PKCθ plays a critical role in T-cell receptor (TCR) signaling, immune synapse formation, and T-cell activation, particularly in response to antigen-presenting cells. It is recruited to the immunological synapse upon TCR engagement, where it mediates downstream signaling pathways, including NF-κB and AP-1 activation, essential for T-cell proliferation, cytokine production, and survival. Dysregulation of PKCθ is implicated in autoimmune diseases, allergic responses, and cancer immunotherapy resistance. The Ab-676 antibody, often utilized in Western blotting, immunofluorescence, and immunoprecipitation, enables researchers to detect PKCθ expression, localization, and activation status in experimental models. Its applications extend to studying PKCθ's involvement in modulating T-cell anergy, regulatory T-cell function, and checkpoint inhibitor responses. As PKCθ inhibition emerges as a therapeutic strategy for autoimmune disorders and a potential target to enhance CAR-T cell efficacy, antibodies like Ab-676 serve as vital reagents for mechanistic and translational research in immunology and oncology.