| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GLURZ1; GRIN1; NMD-R1; NMDZ1; NMZ1 |
| Entrez GeneID | 2902; |
| WB Predicted band size | 120kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.895~899 (R-S-S-K-D) derived from Human NMDAR1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NMDAR1(Ab-897)抗体的模拟参考文献示例(注：具体文献需通过数据库验证)：
1. **文献名称**: "Differential expression of NMDAR1 in hippocampal neurons during synaptic plasticity"
**作者**: Smith A, et al.
**摘要**: 使用NMDAR1(Ab-897)抗体通过免疫组化分析海马神经元中NMDAR1的亚细胞定位，发现其在突触后膜富集，并与长时程增强(LTP)相关。
2. **文献名称**: "NMDAR1 subunit deletion in a mouse model alters cortical network dynamics"
**作者**: Chen L, et al.
**摘要**: 通过Western blot(抗体Ab-897)验证NMDAR1敲除小鼠的蛋白表达缺失，并发现其皮层神经元兴奋性异常。
3. **文献名称**: "Autoantibodies targeting NMDAR1 in autoimmune encephalitis: clinical correlations"
**作者**: Wang Y, et al.
**摘要**: 采用NMDAR1(Ab-897)抗体检测患者脑脊液中NMDAR1自身抗体水平，揭示其与神经精神症状的严重程度相关。
4. **文献名称**: "Post-ischemic modulation of NMDAR1 in a rat stroke model"
**作者**: Kim H, et al.
**摘要**: 利用Ab-897抗体证实脑缺血后NMDAR1在梗死周边区的表达上调，提示其参与缺血后神经元损伤机制。
(注：以上为示例性内容，实际文献需通过PubMed、Google Scholar等平台以“NMDAR1 Ab-897”或“anti-NR1 sc-897”等关键词检索确认。)
**Background of NMDAR1 (Ab-897) Antibody**
The NMDAR1 (Ab-897) antibody is a selective tool designed to target the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor, a critical ionotropic glutamate receptor in the central nervous system. The NR1 subunit serves as the essential core component of NMDA receptors, forming heterotetrameric complexes with NR2 or NR3 subunits to mediate synaptic plasticity, learning, and memory. The antibody, often raised against a specific epitope (e.g., C-terminal regions of NR1), enables the detection of endogenous NR1 proteins in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.
Ab-897 is particularly useful for studying NR1 expression, localization, and post-translational modifications, such as phosphorylation, which regulates receptor trafficking and function. Its specificity makes it valuable in research on neurological disorders linked to NMDA receptor dysregulation, such as schizophrenia, Alzheimer’s disease, and ischemic brain injury. Additionally, the antibody aids in distinguishing splice variants of NR1. which differ in their C-terminal domains and influence receptor properties.
Developed with high affinity and validated across multiple species (e.g., human, rat, mouse), NMDAR1 (Ab-897) supports investigations into glutamate receptor biology, synaptic signaling mechanisms, and therapeutic targeting of NMDA-related pathologies. Its reliability in diverse experimental models underscores its importance in neuroscience research.
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