Rabbit Polyclonal RelB(Ab-573) Antibody

The RelB (Ab-573) antibody is a monoclonal antibody specifically designed to detect RelB, a key subunit of the NF-κB transcription factor family. RelB plays a critical role in regulating immune responses, cell survival, and differentiation through its involvement in the non-canonical NF-κB signaling pathway. Unlike other NF-κB members, RelB forms heterodimers (e.g., with p52) to activate genes associated with lymphoid organ development, B-cell maturation, and dendritic cell function. Dysregulation of RelB has been linked to autoimmune diseases, chronic inflammation, and cancer progression. The Ab-573 antibody, typically generated in rabbits or mice, targets epitopes within the RelB protein, enabling its detection in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity and affinity make it a valuable tool for studying RelB's expression patterns, subcellular localization, and interactions in both physiological and pathological contexts. Researchers often use this antibody to explore RelB's role in immune tolerance, tumor microenvironments, or inflammatory disorders. Validation data, including knockout controls or peptide blocking experiments, are usually provided to confirm its reliability. Commercial suppliers may offer it in varying formats (e.g., purified, conjugated) to accommodate diverse experimental needs.