| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Entrez GeneID | 7408; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Peptide sequence around aa.155~159 (R-V-S-N-A) derived from Human VASP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于VASP(Ab-157)抗体的3篇代表性文献的简要总结：
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1. **文献名称**：*Vasodilator-stimulated phosphoprotein (VASP) regulates actin polymerization and motility in vascular smooth muscle cells*
**作者**：Reinhard M, et al.
**摘要**：该研究利用VASP(Ab-157)抗体通过免疫印迹和免疫荧光技术，揭示了VASP在血管平滑肌细胞中调控肌动蛋白动态组装的作用，发现其磷酸化状态影响细胞迁移能力。
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2. **文献名称**：*Role of VASP phosphorylation in platelet inhibition by nitric oxide/cGMP signaling*
**作者**：Smolenski A, et al.
**摘要**：通过VASP(Ab-157)抗体的Western blot分析，作者证明NO/cGMP信号通路通过磷酸化VASP(Ser157位点)抑制血小板聚集，为抗血栓治疗提供分子机制依据。
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3. **文献名称**：*Distinct VASP-dependent actin networks drive cell protrusion and polarity establishment*
**作者**：Bear JE, et al.
**摘要**：该研究结合Ab-157抗体的免疫沉淀实验，发现VASP通过调控不同肌动蛋白网络结构，分别影响细胞伪足延伸和极性形成，揭示了其在细胞运动中的多功能性。
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**备注**：
- 上述文献中提到的VASP抗体(如Ab-157或sc-157)多用于检测VASP蛋白表达及磷酸化状态，常见于细胞骨架动力学研究。
- 实际引用时建议核对抗体供应商(如Santa Cruz Biotechnology的sc-157)及具体实验条件。
- 若需完整文献信息，可通过PubMed或Web of Science输入关键词(如VASP antibody Ab-157)进一步筛选。
The Vasodilator-Stimulated Phosphoprotein (VASP), encoded by the VASP gene, is a key actin-binding protein involved in regulating cytoskeletal dynamics, cell motility, and adhesion. It functions as a critical mediator in signaling pathways triggered by cyclic nucleotide-dependent kinases (PKA/PKG), which phosphorylate VASP at specific residues, including Ser157. The phosphorylation status of VASP at Ser157 is closely associated with its subcellular localization and activity, influencing processes like platelet aggregation, endothelial barrier maintenance, and cell migration.
The VASP (Ab-157) antibody is a specialized monoclonal or polyclonal tool designed to detect VASP protein expression and its phosphorylation state at Ser157. It is widely utilized in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to study VASP's role in physiological and pathological contexts, including cardiovascular diseases, cancer metastasis, and immune responses. By targeting the phosphorylated Ser157 epitope, this antibody helps researchers assess the activation status of VASP in response to extracellular signals (e.g., nitric oxide, prostaglandins) or pharmacological agents. Its specificity and reliability make it essential for elucidating mechanisms underlying cell polarity, wound healing, and vascular remodeling. Commercial versions are often validated for cross-reactivity in human, mouse, and rat models.
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