Rabbit Polyclonal HSF1(Ab-307) Antibody

HSF1 (Heat Shock Factor 1) is a critical transcription factor that regulates cellular stress responses by activating the expression of heat shock proteins (HSPs) upon exposure to proteotoxic stressors, such as elevated temperatures, oxidative stress, or chemical toxins. HSF1(Ab-307) is a specific monoclonal antibody designed to detect HSF1. particularly targeting phosphorylated serine residues (e.g., Ser307 in humans), a post-translational modification associated with the regulation of HSF1 activity. Phosphorylation at Ser307 is linked to HSF1’s functional modulation, including its nuclear translocation, DNA-binding capacity, and interaction with co-regulators. This antibody is widely used in research to study HSF1’s role in stress adaptation, cancer biology (where HSF1 supports tumor survival and progression), and neurodegenerative diseases. It is validated for applications like Western blotting, immunofluorescence, and immunoprecipitation in human, mouse, and rat samples. By enabling precise detection of HSF1’s activation state, HSF1(Ab-307) helps elucidate mechanisms underlying cellular stress resilience, proteostasis, and disease pathways, making it a valuable tool in both basic and translational biomedical studies.