| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAP kinase kinase 6; MAP2K6; MAPK/ERK kinase 6; MAPKK 6; MEK6 |
| Entrez GeneID | 5608; |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.205~209 (V-D-S-V-A) derived from Human MKK6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MKK6(Ab-207)抗体的3篇参考文献示例(注：内容为模拟生成，实际文献需通过数据库检索确认)：
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1. **文献名称**: "MKK6-p38 Signaling in Cardiac Hypertrophy"
**作者**: Zhang L, et al.
**摘要**: 本研究利用MKK6(Ab-207)抗体通过Western blot和免疫组化分析，验证了MKK6在小鼠心肌肥厚模型中表达上调，并发现其通过激活p38 MAPK通路促进病理性心脏重构。
2. **文献名称**: "Role of MKK6 in TNF-α-Induced Inflammatory Response"
**作者**: Chen R, et al.
**摘要**: 通过MKK6(Ab-207)抗体的免疫沉淀技术，作者发现MKK6在TNF-α刺激下与ASK1形成复合物，调控巨噬细胞中炎症因子IL-6和IL-1β的分泌，提示其在炎症反应中的关键作用。
3. **文献名称**: "MKK6 Phosphorylation Status in Breast Cancer Metastasis"
**作者**: Gupta S, et al.
**摘要**: 该研究使用MKK6(Ab-207)抗体进行免疫荧光染色，发现MKK6在乳腺癌转移组织中呈现高磷酸化状态，且与患者预后不良显著相关，为靶向MKK6-p38通路提供了理论依据。
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**说明**：
- 上述文献为示例，实际引用需检索PubMed、Web of Science等平台，关键词“MKK6 antibody Ab-207”或结合研究主题(如“MKK6 cancer”)。
- 部分厂商(如CST)官网的“参考文献”板块可能直接提供该抗体(产品编号#)的引用文献。
- 若需具体文献，建议补充抗体生产商或应用场景(如WB/IHC)。
The MKK6 (Ab-207) antibody is a monoclonal or polyclonal antibody specifically designed to detect mitogen-activated protein kinase kinase 6 (MKK6), also known as MAP2K6. a key component of the MAPK signaling pathway. MKK6 functions as a dual-specificity kinase that phosphorylates and activates p38 MAP kinase (MAPK14), which regulates cellular responses to stress, cytokines, and growth factors. This pathway is critical in mediating processes like apoptosis, inflammation, cell differentiation, and immune responses. Dysregulation of MKK6/p38 signaling has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions.
The Ab-207 clone is commonly used in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study MKK6 expression, localization, and activation in cell lines, tissues, or preclinical models. It is often validated for specificity through knockdown/knockout controls or peptide-blocking assays to ensure minimal cross-reactivity with related kinases like MKK3 or MKK4. Some versions may detect total MKK6 or phosphorylated forms (e.g., at Ser207/Thr211), depending on the epitope targeted.
As a tool, the MKK6 (Ab-207) antibody aids in elucidating signaling mechanisms in diseases and drug development, particularly in studies exploring p38 MAPK pathway inhibitors. Researchers should verify the antibody’s species reactivity (e.g., human, mouse, rat) and application-specific validation data from product specifications to ensure experimental reproducibility.
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