Rabbit Polyclonal HDAC5(Ab-498) Antibody

The HDAC5 (Ab-498) antibody is a specific monoclonal or polyclonal antibody designed to detect histone deacetylase 5 (HDAC5), a member of the class IIa HDAC family. HDAC5 plays a critical role in epigenetic regulation by catalyzing the removal of acetyl groups from histones, leading to chromatin condensation and transcriptional repression. It is involved in diverse cellular processes, including differentiation, apoptosis, and stress responses, and has been implicated in diseases such as cancer, cardiovascular disorders, and neurological conditions. The "Ab-498" designation typically refers to an antibody targeting a specific phosphorylation site (e.g., Serine 498) or epitope within HDAC5. Phosphorylation at residues like Ser-498 regulates HDAC5's subcellular localization, particularly its nuclear export in response to signaling pathways such as CaMKII, which modulates its interaction with transcription factors (e.g., MEF2). This antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study HDAC5 expression, post-translational modifications, and functional dynamics. Its specificity is often validated using HDAC5 knockout models or phosphorylation-deficient mutants. Researchers employ HDAC5 (Ab-498) to explore mechanisms in gene silencing, metabolic reprogramming, and disease pathways, making it a vital tool for understanding epigenetic regulation and therapeutic targeting.